The Interstate Highway System and its numbering as approved June 27, 1958; several of these numbers were modified by 1960

This is a list of highways, mostly U.S. Routes, bypassed by Interstate Highways. Unless otherwise specified, designations are as of ca. 1960, at the time the final Interstate plan was adopted. Interstates marked as "later addition" were added after the early 1960s. Locations and corridors are approximate.

Interstate 2

• 
  U.S. Route 83, Palmview to Harlingen, Texas (later addition)

Interstate 4

• 
  U.S. Route 92, St. Petersburg, Florida to Daytona Beach, Florida
  

Interstate 5 (including Interstate 5E)

• 
  U.S. Route 101, San Ysidro, California to Los Angeles, California
  


• 
  U.S. Route 99, Los Angeles to Wheeler Ridge, California
  


• New route mostly along the west side of the San Joaquin Valley from Wheeler Ridge to Sacramento, California, but supplanting a short segment of U.S. Route 50 between Tracy, California, and Stockton, California
  


• 
  U.S. Route 99W, Sacramento to Red Bluff, California
  


• 
  U.S. Route 99, Red Bluff to Junction City, Oregon
  


• 
  U.S. Route 99E, Junction City to Portland, Oregon
  


• 
  U.S. Route 99, Portland to Blaine, Washington
  

Interstate 5W (now Interstate 580, Interstate 80 and Interstate 505)

• 
  U.S. Route 50, Stockton to Oakland, California
  


• 
  U.S. Route 40, Oakland to west of Sacramento, California
  


• 
  U.S. Route 99W, west of Sacramento to northwest of Sacramento

Interstate 8

• 
  U.S. Route 80, San Diego, California to Gila Bend, Arizona
  


• 
  Arizona State Route 84, Gila Bend to Casa Grande, Arizona
  

Interstate 10

• 
  U.S. Route 66, Santa Monica to Los Angeles, California
  


• 
  U.S. Route 70 (also parts of U.S. Route 99 and U.S. Route 60), Los Angeles to Brenda, Arizona
  


• New route, Brenda to Phoenix, Arizona^[1]


• 
  U.S. Route 80, Phoenix to Benson, Arizona
  


• 
  Arizona State Route 86 and old New Mexico State Road 14, Benson to Lordsburg, New Mexico
  


• 
  U.S. Route 80, Lordsburg to east of Van Horn, Texas
  


• 
  U.S. Route 290, east of Van Horn to east of Junction, Texas
  


• 
  Texas State Highway 27, east of Junction to Comfort, Texas
  


• 
  U.S. Route 87, Comfort to San Antonio, Texas
  


• 
  U.S. Route 90, San Antonio to Lafayette, Louisiana
  


• New route, Lafayette to Baton Rouge, Louisiana
  


• 
  U.S. Route 61, Baton Rouge to New Orleans, Louisiana
  


• 
  U.S. Route 90, New Orleans to Jacksonville, Florida
  

Interstate 12

• 
  U.S. Route 190, Baton Rouge to Slidell, Louisiana
  

Interstate 15

• 
  U.S. Route 395, San Diego to San Bernardino, California (added 1968)


• 
  U.S. Route 91, San Bernardino to Sweetgrass, Montana
  

Interstate 15W (Idaho) (now Interstate 86)

• 
  U.S. Route 30N, Burley to Pocatello, Idaho
  

Interstate 16

• 
  U.S. Route 80, Macon to Savannah, Georgia
  

Interstate 17

• 
  Arizona State Route 69, Phoenix to Cordes Junction, Arizona
  


• New route, Cordes Junction to Camp Verde, Arizona
  


• Old Arizona State Route 79, Camp Verde to Flagstaff, Arizona
  

Interstate 19

• 
  U.S. Route 89, Nogales to Tucson, Arizona
  

Interstate 20

• 
  U.S. Route 80, east of Van Horn, Texas to Meridian, Mississippi
  


• 
  U.S. Route 11, Meridian to Birmingham, Alabama
  


• 
  U.S. Route 78, Birmingham to Atlanta, Georgia
  


• 
  U.S. Route 278, Atlanta to Augusta, Georgia
  


• 
  U.S. Route 1, Augusta to Columbia, South Carolina
  


• 
  U.S. Route 76, Columbia to Florence, South Carolina
  

Interstate 22

• 
  U.S. Route 78, Memphis, Tennessee to Birmingham, Alabama (later addition)

Interstate 24

• 
  Illinois Route 37, south of Marion, Illinois to Vienna, Illinois
  


• 
  U.S. Route 45, Vienna to Paducah, Kentucky
  


• 
  U.S. Route 62, Paducah to Eddyville, Kentucky
  


• New route (roughly along Kentucky highways 93, 117, & 128), Eddyville to Oak Grove, Kentucky
  


• 
  U.S. Route 41, Oak Grove to Chattanooga, Tennessee
  

Interstate 25

• 
  U.S. Route 85, Las Cruces, New Mexico to Denver, Colorado
  


• 
  U.S. Route 87, Raton, New Mexico to Buffalo, Wyoming
  

Interstate 26

• 
  U.S. Route 23, Kingsport, Tennessee to Asheville, North Carolina (later addition)


• 
  U.S. Route 25, Asheville to Hendersonville, North Carolina
  


• 
  U.S. Route 176, Hendersonville to Spartanburg, South Carolina
  


• 
  U.S. Route 221 Spartanburg to Laurens, South Carolina
  


• 
  U.S. Route 76, Laurens to Columbia, South Carolina
  


• 
  U.S. Route 176, Columbia to Goose Creek, South Carolina
  


• 
  U.S. Route 52, Goose Creek to Charleston, South Carolina
  

Interstate 27

• 
  U.S. Route 87, Lubbock to Amarillo, Texas (later addition)

Interstate 29

• 
  U.S. Route 71, Kansas City to St. Joseph, Missouri
  


• 
  U.S. Route 275, St. Joseph to Council Bluffs, Iowa
  


• 
  U.S. Route 75, Council Bluffs to Sioux City, Iowa
  


• 
  U.S. Route 77, Sioux City to Watertown, South Dakota
  


• 
  U.S. Route 81, Watertown to Pembina, North Dakota
  

Interstate 30

• 
  U.S. Route 80, Aledo, Texas to Dallas, Texas (later addition)


• 
  U.S. Route 67, Dallas to Little Rock, Arkansas
  

Interstate 35 (including Interstate 35E (Texas))

• 
  U.S. Route 81, Laredo to Hillsboro, Texas
  


• 
  U.S. Route 77, Hillsboro to Tonkawa, Oklahoma
  


• 
  U.S. Route 177, Tonkawa to South Haven, Kansas
  


• 
  U.S. Route 81, South Haven to Wichita, Kansas
  


• New Route roughly along U.S. Route 54 & K-99 (Kansas Highway) Wichita to Emporia, Kansas
  


• 
  U.S. Route 50, Emporia to Overland Park, Kansas
  


• 
  U.S. Route 69, Overland Park to Albert Lea, Minnesota
  


• 
  U.S. Route 65, Albert Lea to Minneapolis–Saint Paul, Minnesota
  


• 
  U.S. Route 61, Minneapolis–Saint Paul to Duluth, Minnesota
  

Interstate 35W (Texas)

• 
  U.S. Route 81, Hillsboro, Texas to Fort Worth, Texas
  


• 
  U.S. Route 377, Fort Worth to Denton, Texas
  

Interstate 35W (Kansas) (now Interstate 135)

• 
  U.S. Route 81, Wichita, Kansas to Salina, Kansas
  

Interstate 37

• 
  Texas State Highway 9 (roughly along the path of U.S. Route 181), Corpus Christi to north of George West, Texas
  


• 
  U.S. Route 281, north of George West to San Antonio, Texas
  

Interstate 39

• 
  U.S. Route 51, Bloomington–Normal, Illinois to Wausau, Wisconsin (later addition)

Interstate 40

• 
  U.S. Route 66, Barstow, California to Oklahoma City, Oklahoma
  


• 
  U.S. Route 62, Oklahoma City to Henryetta, Oklahoma
  


• 
  U.S. Route 266, Henryetta to Warner, Oklahoma
  


• 
  U.S. Route 64, Warner to Conway, Arkansas
  


• 
  U.S. Route 65, Conway to Little Rock, Arkansas
  


• 
  U.S. Route 70, Little Rock to Statesville, North Carolina
  


• 
  U.S. Route 64, Statesville to Mocksville, North Carolina
  


• 
  U.S. Route 158, Mocksville to Winston-Salem, North Carolina
  


• 
  U.S. Route 421, Winston-Salem to Greensboro, North Carolina
  


• 
  U.S. Route 70, Greensboro to Garner, North Carolina
  


• 
  North Carolina Highway 50, Garner to Faison, North Carolina (later addition)


• 
  U.S. Route 117, Faison to Wilmington, North Carolina (later addition)

Interstate 41

• 
  U.S. Route 41 (roughly along the path of U.S. Route 45), Russell, Illinois to Howard, Wisconsin (later addition)

Interstate 43

• 
  Wisconsin Highway 15, Beloit to Milwaukee, Wisconsin (later addition)


• 
  U.S. Route 141, Milwaukee to Green Bay, Wisconsin (later addition)

Interstate 44

• 
  U.S. Route 277, Wichita Falls, Texas to Oklahoma City, Oklahoma (later addition)


• 
  U.S. Route 66, Oklahoma City to St. Louis, Missouri
  

Interstate 45

• 
  U.S. Route 75, Galveston, Texas to Dallas, Texas
  

Interstate 49

• 
  U.S. Route 167, Lafayette to Alexandria, Louisiana (later addition)


• 
  Louisiana Highway 1 (roughly along the path of U.S. Route 71), Alexandria to Shreveport, Louisiana
  


• 
  U.S. Route 71, Pineville to Kansas City, Missouri (later addition)

Interstate 55

• 
  U.S. Route 51, New Orleans, Louisiana to Memphis, Tennessee
  


• 
  U.S. Route 61, Memphis to St. Louis, Missouri
  


• 
  U.S. Route 66, St. Louis to Chicago, Illinois
  

Interstate 57

• 
  U.S. Route 60, Sikeston, Missouri to Cairo, Illinois
  


• 
  Illinois Route 37 (roughly along the path of U.S. Route 51), Cairo to Effingham, Illinois
  


• 
  U.S. Route 45, Effingham to Chicago, Illinois
  

Interstate 59

• 
  U.S. Route 11, Slidell, Louisiana to Chattanooga, Tennessee
  

Interstate 64

• 
  U.S. Route 460, St. Louis, Missouri to Louisville, Kentucky
  


• 
  U.S. Route 60, Louisville to Lexington, Virginia
  


• 
  U.S. Route 11, Lexington to Staunton, Virginia
  


• 
  U.S. Route 250, Staunton to Richmond, Virginia
  


• 
  U.S. Route 60, Richmond to Norfolk, Virginia
  

Interstate 65

• 
  U.S. Route 31, Mobile, Alabama to Nashville, Tennessee
  


• 
  U.S. Route 31W, Nashville to Louisville, Kentucky
  


• 
  U.S. Route 31, Louisville to Indianapolis, Indiana
  


• 
  U.S. Route 52, Indianapolis to Lafayette, Indiana
  


• 
  U.S. Route 231, Lafayette to Crown Point, Indiana
  


• 
  U.S. Route 41, Crown Point to Gary, Indiana
  

Interstate 66

• 
  Virginia State Route 55, Strasburg to east of Warrenton, Virginia
  


• 
  U.S. Route 29, east of Warrenton to Washington, D.C.
  

Interstate 68

• 
  West Virginia Route 73, West Virginia Route 26, Pennsylvania Route 281 and U.S. Route 40, Morgantown, West Virginia to Hancock, Maryland (later addition)

Interstate 69

• 
  U.S. Route 59, Rosenberg to Cleveland, Texas (later addition)


• 
  Mississippi Highway 304, Banks to Hernando, Mississippi (later addition)


• 
  U.S. Route 51, Hernando, Mississippi to Memphis, Tennessee (later addition)


• 
  U.S. Route 62, Calvert City to Nortonville, Kentucky (later addition)


• 
  U.S. Route 41, Nortonville to Madisonville, Kentucky (later addition)


• 
  Indiana State Road 57, Elberfield to Crane, Indiana (later addition)


• 
  Indiana State Road 37, Indianapolis to Fort Wayne, Indiana
  


• 
  U.S. Route 27, Fort Wayne to Marshall, Michigan
  


• 
  U.S. Route 27, Marshall to Lansing, Michigan (later addition)


• 
  M-78, Lansing to Flint, Michigan (later addition)


• 
  M-21, Flint to Port Huron, Michigan (later addition)

Interstate 69C

• 
  U.S. Route 281, Pharr to Edinburg, Texas (later addition)

Interstate 69E

• 
  U.S. Route 77, Brownsville to Raymondville, Texas and Robstown to Corpus Christi, Texas (later addition)

Interstate 70 (including Interstate 70N)

• New route, Cove Fort, Utah to Sevier, Utah
  


• 
  U.S. Route 89, Sevier to Salina, Utah
  


• 
  U.S. Route 50, Salina to Grand Junction, Colorado
  


• 
  U.S. Route 6, Grand Junction to Denver, Colorado
  


• 
  U.S. Route 40, Denver to Limon, Colorado
  


• 
  U.S. Route 24, Limon to Oakley, Kansas
  


• 
  U.S. Route 40, Oakley to Washington, Pennsylvania
  


• 
  U.S. Route 19, Washington to Pittsburgh, Pennsylvania
  


• 
  U.S. Route 30, Pittsburgh to Breezewood, Pennsylvania
  


• 
  Pennsylvania Route 126 and U.S. Route 522, Breezewood to Hancock, Maryland
  


• 
  U.S. Route 40, Hancock to Baltimore, Maryland
  

Interstate 70S (Pennsylvania)

• 
  Pennsylvania Route 71, Washington to Greensburg, Pennsylvania
  

Interstate 70S (Maryland) (now Interstate 270)

• 
  U.S. Route 240, Frederick, Maryland to Washington, D.C.
  

Interstate 71

• 
  U.S. Route 42, Louisville, Kentucky to Cincinnati, Ohio
  


• 
  U.S. Route 22, Cincinnati to Washington Court House, Ohio
  


• 
  U.S. Route 62, Washington Court House to Columbus, Ohio
  


• 
  U.S. Route 23, Columbus to Delaware, Ohio
  


• 
  U.S. Route 42, Delaware to Cleveland, Ohio
  

Interstate 72

• 
  U.S. Route 36, Hannibal, Missouri to Champaign–Urbana, Illinois (later addition)


• 
  U.S. Route 54, Pittsfield to Springfield, Illinois (later addition)

Interstate 73

• 
  U.S. Route 220, Rockingham to Greensboro, North Carolina (later addition)

Interstate 74

• 
  U.S. Route 150, Moline, Illinois to Danville, Illinois
  


• 
  U.S. Route 136, Danville to Indianapolis, Indiana
  


• 
  U.S. Route 52, Indianapolis to Cincinnati, Ohio
  


• 
  U.S. Route 52, Mount Airy to Winston-Salem, North Carolina (later addition)


• 
  U.S. Route 311, Winston-Salem to Asheboro, North Carolina (later addition)


• 
  U.S. Route 220, Asheboro to Rockingham, North Carolina (later addition)

Interstate 75

• 
  U.S. Route 41, Hialeah, Florida to Chattanooga, Tennessee
  


• 
  U.S. Route 11, Chattanooga to Knoxville, Tennessee
  


• 
  U.S. Route 25W, Knoxville to Corbin, Kentucky
  


• 
  U.S. Route 25, Corbin to Detroit, Michigan
  


• 
  U.S. Route 10, Detroit to Bay City, Michigan
  


• 
  M-76, Bay City to Grayling, Michigan
  


• 
  U.S. Route 27, Grayling to St. Ignace, Michigan
  


• 
  U.S. Route 2, St. Ignace to Sault Ste. Marie, Michigan
  

Interstate 77

• 
  U.S. Route 21, Columbia, South Carolina to Charlotte, North Carolina (later addition)


• 
  U.S. Route 21, Charlotte to Cleveland, Ohio
  

Interstate 78

• 
  U.S. Route 22, Harrisburg, Pennsylvania to New York, New York
  

Interstate 79

• 
  U.S. Route 119, Charleston to Weston, West Virginia (added in 1963)


• 
  U.S. Route 19, Weston to Pittsburgh, Pennsylvania (added in 1963)


• 
  U.S. Route 19, Pittsburgh to Erie, Pennsylvania
  

Interstate 80

• 
  U.S. Route 40, San Francisco, California to east of Salt Lake City, Utah
  


• 
  U.S. Route 189, East of Salt Lake City to Echo, Utah
  


• 
  U.S. Route 30S, Echo to Granger, Wyoming
  


• 
  U.S. Route 30, Granger to Grand Island, Nebraska
  


• 
  U.S. Route 34, Grand Island to Lincoln, Nebraska
  


• 
  U.S. Route 6, Lincoln to Chicago, Illinois
  


• 
  U.S. Route 20, Chicago to Norwalk, Ohio
  


• 
  Ohio State Route 18, Norwalk to Youngstown, Ohio
  


• New route (partly U.S. Route 62 and U.S. Route 322), Youngstown to Stroudsburg, Pennsylvania
  


• 
  U.S. Route 46, Stroudsburg to New York, New York
  

Interstate 80N (Oregon-Idaho-Utah) (now Interstate 84)

• 
  U.S. Route 30, Portland, Oregon to Burley, Idaho
  


• 
  U.S. Route 30S, Burley to Echo, Utah
  

Interstate 80S (Colorado) (now Interstate 76)

• 
  U.S. Route 6, Denver, Colorado to Sterling, Colorado
  


• 
  U.S. Route 138, Sterling to Big Springs, Nebraska
  

Interstate 80S (Pennsylvania) (now Interstate 76)

• 
  Ohio State Route 14 and Pennsylvania Route 51, Youngstown, Ohio to Pittsburgh, Pennsylvania
  


• 
  U.S. Route 30, Pittsburgh to Chambersburg, Pennsylvania
  


• 
  U.S. Route 11, Chambersburg to Harrisburg, Pennsylvania
  


• 
  U.S. Route 322, Harrisburg to Downingtown, Pennsylvania
  


• 
  U.S. Route 30, Downingtown to Philadelphia, Pennsylvania
  

Interstate 580 (California)

• 
  U.S. Route 50, Oakland to Tracy, California
  


• 
  California State Route 33 around Tracy, California
  

The above segment was originally designated as Interstate 5W.

• 
  State Route 17 Oakland to San Rafael, California (later addition)

Interstate 81

• 
  U.S. Route 11, Dandridge, Tennessee to Harrisburg, Pennsylvania
  


• New route, Harrisburg to Scranton, Pennsylvania
  


• 
  U.S. Route 11, Scranton to Watertown, New York
  


• 
  New York State Route 180, Watertown to north of Clayton, New York
  

Interstate 81E (now Interstate 380)

• 
  U.S. Route 611, Stroudsburg to Scranton, Pennsylvania
  

Interstate 82

• 
  U.S. Route 97, Ellensburg to Toppenish, Washington
  


• 
  U.S. Route 410, Toppenish to Pasco, Washington
  


• 
  U.S. Route 395, Pasco to Umatilla, Oregon
  

Interstate 83

• 
  U.S. Route 111, Baltimore, Maryland to Harrisburg, Pennsylvania
  

Interstate 84

• 
  U.S. Route 6, Scranton, Pennsylvania to Hartford, Connecticut
  


• 
  Connecticut Route 15 and Massachusetts Route 15, Hartford to Sturbridge, Massachusetts
  

Interstate 84

• 
  U.S. Route 30, Portland, Oregon to Junction with Interstate 86
  


• 
  U.S. Route 20, Caldwell to Mountain Home, Idaho
  


• 
  U.S. Route 26, Caldwell to Bliss, Idaho
  

Interstate 85

• 
  U.S. Route 80, Montgomery, Alabama to Tuskegee, Alabama
  


• 
  U.S. Route 29, Tuskegee to Greensboro, North Carolina
  


• 
  U.S. Route 70, Greensboro to Durham, North Carolina
  


• 
  U.S. Route 15, Durham to Oxford, North Carolina
  


• 
  U.S. Route 158, Oxford to Henderson, North Carolina
  


• 
  U.S. Route 1, Henderson to Petersburg, Virginia
  

Interstate 86

• 
  U.S. Route 30, Declo to Chubbuck
  

Interstate 86

• 
  Pennsylvania Route 17 and New York State Route 17, Erie, Pennsylvania to Harriman, New York (later addition)

Interstate 87

• 
  U.S. Route 9 and U.S. Route 9W, New York City to Albany, New York
  


• 
  U.S. Route 9, Albany to Champlain, New York
  

Interstate 88

• 
  Illinois State Route 5, Quad Cities to Sterling, Illinois (later addition)


• 
  U.S. Route 30, Sterling to Aurora, Illinois (later addition)


• 
  U.S. Route 34, Aurora to Chicago, Illinois (later addition)

Interstate 88

• 
  New York State Route 7, Binghamton to Schenectady, New York (later addition)

Interstate 89

• 
  U.S. Route 4, White River Junction, Vermont to Concord, New Hampshire
  


• 
  Vermont Route 14, White River Junction to Montpelier, Vermont
  


• 
  U.S. Route 2, Montpelier to Burlington, Vermont
  


• 
  U.S. Route 7, Burlington to north of St. Albans, Vermont
  

Interstate 90

• 
  U.S. Route 10, Seattle, Washington to Billings, Montana
  


• 
  U.S. Route 87, Billings to Buffalo, Wyoming
  


• 
  U.S. Route 14, Buffalo to Rapid City, South Dakota
  


• 
  U.S. Route 16, Rapid City to Portage, Wisconsin
  


• 
  U.S. Route 51, Portage to Rockford, Illinois
  


• 
  U.S. Route 20, Rockford to Boston, Massachusetts
  

Interstate 91

• 
  U.S. Route 5, New Haven, Connecticut to Canada–United States border
  

Interstate 93

• 
  U.S. Route 3, Boston, Massachusetts to Franconia, New Hampshire
  


• 
  New Hampshire Route 18 and Vermont Route 18, Franconia to St. Johnsbury, Vermont
  

Interstate 94

• 
  U.S. Route 10, Billings, Montana to Fargo, North Dakota
  


• 
  U.S. Route 52, Fargo to Minneapolis–Saint Paul, Minnesota
  


• 
  U.S. Route 12, Minneapolis–Saint Paul to Madison, Wisconsin
  


• 
  U.S. Route 18, Madison to Milwaukee, Wisconsin
  


• 
  U.S. Route 41, Milwaukee to Chicago, Illinois
  


• 
  U.S. Route 12, Chicago to Detroit, Michigan
  


• 
  U.S. Route 25, Detroit to Canada–United States border
  

Interstate 95

• 
  U.S. Route 1, Miami to Jacksonville, Florida
  


• 
  U.S. Route 17, Jacksonville to Walterboro, South Carolina
  


• 
  U.S. Route 15, Walterboro to Summerton, South Carolina
  


• 
  U.S. Route 301, Summerton to Petersburg, Virginia
  


• 
  U.S. Route 1, Petersburg to Baltimore, Maryland
  


• 
  U.S. Route 40, Baltimore to Wilmington, Delaware
  


• 
  U.S. Route 13, Wilmington to Trenton, New Jersey
  


• 
  U.S. Route 1, Trenton to Brunswick, Maine
  


• 
  U.S. Route 201, Brunswick to Waterville, Maine
  


• 
  Maine State Route 11, Waterville to Newport, Maine
  


• 
  U.S. Route 2, Newport to Houlton, Maine
  

Interstate 195 (Rhode Island–Massachusetts)

• 
  U.S. Route 6, Providence, Rhode Island to Wareham, Massachusetts
  

Interstate 96 (now partly Interstate 196)

• 
  U.S. Route 31, Benton Harbor to Holland, Michigan
  


• 
  M-21, Holland to Grand Rapids, Michigan
  


• 
  U.S. Route 16, Grand Rapids to Detroit, Michigan
  

Interstate 196 (now Interstate 96)

• 
  U.S. Route 16, Muskegon to Grand Rapids, Michigan
  

Interstate 97

• 
  Maryland Route 178 and Maryland Route 3, Annapolis to Baltimore, Maryland (later addition)

Interstate 99

• 
  U.S. Route 220, Bedford to State College, Pennsylvania (later addition)

Interstate 238

• 
  California State Route 238, Castro Valley to San Leandro, California (later addition)

References[edit]