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Resveratrol








Resveratrol


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Resveratrol

Chemical 9–69 structure of trans-resveratrol

Chemical structure of trans-resveratrol

Chemical structures of cis- and trans-resveratrols
Chemical structures of cis- ((Z)-resveratrol, left) and trans-resveratrol ((E)-resveratrol, right)[1]

Names
Other names

trans-3,5,4′-Trihydroxystilbene;
3,4′,5-Stilbenetriol;
trans-Resveratrol;
(E)-5-(p-Hydroxystyryl)resorcinol;
(E)-5-(4-hydroxystyryl)benzene-1,3-diol

Identifiers

CAS Number



  • 501-36-0 ☑Y


3D model (JSmol)


  • Interactive image


ChEBI


  • CHEBI:45713 ☑Y


ChEMBL


  • ChEMBL165 ☑Y


ChemSpider


  • 392875 ☑Y


DrugBank


  • DB02709 ☑Y


ECHA InfoCard

100.121.386

KEGG


  • C03582 ☑Y



PubChem CID


  • 445154


RTECS number
CZ8987000

UNII


  • Q369O8926L ☑Y





Properties

Chemical formula


C14H12O3

Molar mass
228.25 g·mol−1
Appearance
white powder with
slight yellow cast

Melting point
261 to 263 °C (502 to 505 °F; 534 to 536 K)[2]

Solubility in water
0.03 g/L

Solubility in DMSO
16 g/L

Solubility in ethanol
50 g/L

UV-vis (λmax)
304nm (trans-resveratrol, in water)
286nm (cis-resveratrol, in water)[1]
Hazards

Safety data sheet
Fisher Scientific[2]
Sigma Aldrich[3]

R-phrases (outdated)

R36 (irritating to eyes)[3]

S-phrases (outdated)

S26 (in case of contact with eyes, rinse immediately with plenty of water and seek medical advice)[3]
Lethal dose or concentration (LD, LC):


LD50 (median dose)

23.2 µM (5.29 g)[4]

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).


☑Y verify (what is ☑Y☒N ?)

Infobox references




UV visible spectrum of trans-resveratrol


Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi.[5][6] Sources of resveratrol in food include the skin of grapes, blueberries, raspberries, mulberries, and peanuts.[7][8]


Although it is used as a dietary supplement, there is no good evidence that consuming resveratrol affects life expectancy or human health.[9][10]


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Contents





  • 1 Health effects

    • 1.1 Heart disease


    • 1.2 Cancer


    • 1.3 Metabolism


    • 1.4 Lifespan



  • 2 Adverse effects


  • 3 Pharmacology

    • 3.1 Pharmacodynamics


    • 3.2 Pharmacokinetics

      • 3.2.1 Metabolism




  • 4 Chemistry

    • 4.1 Biosynthesis


    • 4.2 Biotransformation



  • 5 Occurrences

    • 5.1 Plants


    • 5.2 Foods

      • 5.2.1 Wine and grape juice


      • 5.2.2 Selected foods



    • 5.3 Dietary supplements



  • 6 History


  • 7 Research

    • 7.1 Cancer


    • 7.2 Neurological studies


    • 7.3 Cardiovascular studies


    • 7.4 Diabetes


    • 7.5 Skin



  • 8 Related compounds


  • 9 See also


  • 10 References


  • 11 External links




Health effects[edit]



Heart disease[edit]


There is no evidence of benefit from resveratrol in those who already have heart disease.[11] A 2014 Chinese meta-analysis found a statistically significant 11.90 mmHg reduction in systolic blood pressure from resveratrol doses of 150 mg/day.[12]



Cancer[edit]


As of 2014[update], there is no evidence of an effect of resveratrol on cancer in humans.[13]



Metabolism[edit]


There is no conclusive evidence for an effect of resveratrol on human metabolism.[14][15]



Lifespan[edit]


There is no evidence for an effect of resveratrol on lifespan in humans as of 2011[update].[16]



Adverse effects[edit]


A limited number of human studies have shown resveratrol is generally well-tolerated.[17][15]


A 2018 review of 17 clinical trials on the effects of resveratrol on blood pressure found that one person taking a 1000 mg daily dose developed an itchy rash that resolved after discontinuation, and that in four of the trials, people had increased frequency of bowel movements and loose stools in first month of the trial.[17] In a year long preliminary clinical trial in people with Alzheimer's disease, the most frequent adverse effects were diarrhea, weight loss, and nausea.[18]



Pharmacology[edit]



Pharmacodynamics[edit]


Resveratrol has been identified as a pan-assay interference compound, which produces positive results in many different laboratory assays.[19] Its ability for varied interactions may be due to direct effects on cell membranes.[20]


As of 2015, many specific biological targets for resveratrol had been identified or identified, including NQO2 (alone and in interaction with AKT1), GSTP1, estrogen receptor beta, CBR1, and integrin αVβ. It was unclear at that time if any or all of these were responsible for the observed effects in cells and model organisms.[21]


In vitro studies indicate resveratrol activates sirtuin 1,[22] although this may be a downstream effect from its immediate biological target(s).[23][24] It appears to signal through PGC-1α, thereby affecting mitochondria.[25] In cells treated with resveratrol, an increase is observed in the action of MnSOD (SOD2)[26] and in GPER activity.[27] In vitro, resveratrol was shown to act as an agonist of Peroxisome proliferator-activated receptor gamma, a nuclear receptor under pharmacological research as a potential treatment for type 2 diabetes.[28]



Pharmacokinetics[edit]


One way of administering resveratrol in humans may be buccal delivery by direct absorption through the saliva. However, the viability of a buccal delivery method is unlikely due to the low aqueous solubility of the molecule.[29][30] The bioavailability of resveratrol is about 0.5% due to extensive hepatic glucuronidation and sulfation.[31]



Metabolism[edit]


Resveratrol gets extensively metabolized in the body, with the liver and lungs as the major sites of its metabolism.[32]



Chemistry[edit]


Resveratrol (3,5,4'-trihydroxystilbene) is a stilbenoid, a derivative of stilbene.


It exists as two geometric isomers: cis- (Z) and trans- (E), with the trans-isomer shown in the top image. The trans- and cis-resveratrol can be either free or bound to glucose.[33]


The trans- form can undergo isomerization to the cis- form when exposed to ultraviolet irradiation,[34] a process called photoisomerization:[35]




Resveratrol photoisomerization



One study showed that ultraviolet irradiation to cis-resveratrol induces further photochemical reaction, producing a fluorescent molecule named "Resveratrone".[36]


Trans-resveratrol in the powder form was found to be stable under "accelerated stability" conditions of 75% humidity and 40 °C in the presence of air.[37] The trans isomer is also stabilized by the presence of transport proteins.[38] Resveratrol content also was stable in the skins of grapes and pomace taken after fermentation and stored for a long period.[39]lH- and 13C-NMR data for the four most common forms of resveratrols are reported in literature.[33]



Biosynthesis[edit]


Resveratrol is produced in plants by the action of the enzyme, resveratrol synthase.[40]



Biotransformation[edit]


The grapevine fungal pathogen Botrytis cinerea is able to oxidise resveratrol into metabolites showing attenuated antifungal activities. Those include the resveratrol dimers restrytisol A, B, and C, resveratrol trans-dehydrodimer, leachinol F, and pallidol.[41] The soil bacterium Bacillus cereus can be used to transform resveratrol into piceid (resveratrol 3-O-beta-D-glucoside).[42]



Occurrences[edit]



Plants[edit]


Resveratrol is a phytoalexin, a class of compounds produced by many plants when they are infected by pathogens or physically harmed by cutting, crushing, or ultraviolet radiation.[43]


Plants that synthesize resveratrol include knotweeds, pine trees including Scots pine and Eastern white pine, grape vines, peanut plants, cocoa bushes, and Vaccinium shrubs that produce berries, including blueberries, raspberries, mulberries, cranberries, and bilberries.[5][7][43]



Foods[edit]


The levels of resveratrol found in food varies considerably, even in the same food from season to season and batch to batch.[5]



Wine and grape juice[edit]





















Beverage
Resveratrol (mg/150 ml)[8]
meanrange
Red wine
0.270 — 2.78
Rosé wine
0.12
6997500000000000000♠5.00×10−03 — 0.29
White wine
0.040.00 — 0.17
Sparkling wine
6997900000000000000♠9.00×10−03
6997800000000000000♠8.00×10−036998100000000000000♠1.00×10−02
Green grape juice
6997508000000000000♠5.08×10−030.00 — 6998100000000000000♠1.00×10−02

In a 2007 review of published resveratrol concentrations, the average in red wines is 6994189999999999999♠1.9±1.7 mg trans-resveratrol/L (7000819999999999999♠8.2±7.5 µM, ranging from nondetectable levels to 14.3 mg/l (62.7 μM) trans-resveratrol. Levels of cis-resveratrol follow the same trend as trans-resveratrol.[44]


In general, wines made from grapes of the Pinot Noir and St. Laurent varieties showed the highest level of trans-resveratrol, though no wine or region can yet be said to produce wines with significantly higher concentrations than any other wine or region.[44]Champagne and vinegar also contain appreciable levels of resveratrol.[8]


Red wine contains between 0.2 and 5.8 mg/l, depending on the grape variety. White wine has much less because red wine is fermented with the skins, allowing the wine to extract the resveratrol, whereas white wine is fermented after the skin has been removed.[5] The composition of wine is different from that of grapes since the extraction of resveratrol from grapes depends on the duration of the skin contact, and the resveratrol 3-glucosides are in part hydrolysed, yielding both trans- and cis-resveratrol.[5]



Selected foods[edit]

















Food
Serving
Total resveratrol (mg)[5]
Peanuts (raw)
1 cup (146 grams)
0.01 – 0.26
Peanut butter
1 cup (258 grams)
0.04 – 0.13
Red grapes
1 cup (160 grams)
0.24 – 1.25
Cocoa powder
1 cup (200 grams)
0.28 – 0.46

Ounce for ounce, peanuts have about 25% as much resveratrol as red wine.[5]Peanuts, especially sprouted peanuts, have a content similar to grapes in a range of 2.3 to 4.5 μg/g before sprouting, and after sprouting, in a range of 11.7 to 25.7 μg/g, depending upon peanut cultivar.[43][8]


Mulberries (especially the skin) are a source of as much as 50 micrograms of resveratrol per gram dry weight.[45]



Dietary supplements[edit]


Sales of resveratrol supplements increased in 2006 after studies on non-humans.[46]


Harvard University scientist and professor David Sinclair co-founded Sirtris Pharmaceuticals, the initial product of which was a resveratrol formulation;[47] Sinclair became known for making statements about resveratrol like: “(It's) as close to a miraculous molecule as you can find.... One hundred years from now, people will maybe be taking these molecules on a daily basis to prevent heart disease, stroke, and cancer.”[48] Most of the anti-aging field was more cautious, especially with regard to what else resveratrol might do in the body and its lack of bioavailability.[48][49]


Sinclair and others obtained significant news coverage about resveratrol.[50][51] Sinclair is often quoted and pictured in online ads for resveratrol supplements, many of which implied endorsement of the advertised product even though Sinclair had not endorsed them.[52]



History[edit]


The first mention of resveratrol was in a Japanese article in 1939 by Michio Takaoka, who isolated it from Veratrum album, variety grandiflorum, and later, in 1963, from the roots of Japanese knotweed.[43][53][54][55]



Research[edit]


A 2011 systematic review of existing resveratrol research demonstrated there was not enough evidence to demonstrate its effect on longevity or human diseases, nor could there be recommendations for intake beyond the amount normally obtained through dietary sources, estimated as being less than 4 mg/day.[9] Much of the research showing positive effects has been done on animals, with insufficient clinical research on humans.[9] Resveratrol research in animals and humans remains active.[56][57]



Cancer[edit]


As of 2014[update], the results of studies on laboratory animals or human clinical trials concerning the effects of resveratrol on cancer are inconsistent,[13] even if massive doses of resveratrol are used.[58]



Neurological studies[edit]


Resveratrol is under preliminary research for its potential to limit secondary damage after ischemic stroke or acute brain trauma,[59] and its possible effect on cognition.[18]



Cardiovascular studies[edit]


A 2018 meta-analysis found no effect on systolic or diastolic blood pressure; a sub-analysis revealed a 2 mmHg decrease in systolic pressure only from resveratrol doses of 300 mg per day, and only in diabetic people.[17] A 2015 meta-analysis found no effect on systolic or diastolic blood pressure; a sub-analysis found a 11.90 mmHg reduction in systolic blood pressure from resveratrol doses of 150 mg per day.[12]



Diabetes[edit]


One 2015 review found little evidence for use of resveratrol to treat diabetes.[60] A 2015 meta-analysis found little evidence for an effect of resveratrol on diabetes biomarkers.[61]



Skin[edit]


Despite considerable in vitro and animal research, there is no evidence that resveratrol taken orally or topically has any effect on human skin.[62] Preliminary studies have been conducted on resveratrol to understand its potential as a therapy for melanoma.[63][64]



Related compounds[edit]


  • Dihydro-resveratrol


  • Epsilon-viniferin, Pallidol and Quadrangularin A three different resveratrol dimers


  • Trans-diptoindonesin B, a resveratrol trimer


  • Hopeaphenol, a resveratrol tetramer


  • Oxyresveratrol, the aglycone of mulberroside A, a compound found in Morus alba, the white mulberry[65]


  • Piceatannol, an active metabolite of resveratrol found in red wine


  • Piceid, a resveratrol glucoside


  • Pterostilbene, a doubly methylated resveratrol


  • 4'-Methoxy-(E)-resveratrol 3-O-rutinoside, a compound found in the stem bark of Boswellia dalzielii[66]


  • Rhaponticin a glucoside of the stilbenoid rhapontigenin, found in rhubarb rhizomes


See also[edit]




  • Phenolic compounds in wine

  • Polyphenol antioxidant

  • Wine and health

  • List of phytochemicals in food

  • Nutrition

  • Phytochemistry

  • Secondary metabolites



References[edit]




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