谷氨酸脱氢酶

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谷氨酸脱氢酶
識別
符號

GLUD1
替換符號
GLUD

Entrez

2746

HUGO

4335

OMIM

138130

RefSeq

NM_005271

UniProt

P00367
其他資料

EC編號

1.4.1.3

基因座

10 q21.1-24.3

谷氨酸脱氢酶[NAD(P)+]是变构酶的一种,该酶通过氧化脱氢、转氨、联合脱氢和非氧化脱氢,等反应在体内产生。其中以联合脱氢最为重要,它催化可逆反应。



反应


  • 催化反应: L-谷氨酸+H2O+NAD+⇔α-酮戊二酸+NH3+NADH


參考文獻


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  1. Olson, J.A. and Anfinsen, C.B. The crystallization and characterization of L-glutamic acid dehydrogenase. J. Biol. Chem. 197 (1952) 67-79.

  2. Smith, E.L., Austen, B.M., Blumenthal, K.M. and Nyc, J.F. Glutamate dehydrogenases. In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 11, Academic Press, New York, 1975, p. 293-367.

  3. Strecker, H.J. Glutamic dehydrogenase. Arch. Biochem. Biophys. 46 (1953) 128-140.


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