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IFNB1








IFNB1


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IFNB1
Protein IFNB1 PDB 1au1.png


Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases
IFNB1, IFB, IFF, IFNB, IFN-beta, interferon beta 1
External IDsMGI: 107657 HomoloGene: 1640 GeneCards: IFNB1








Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]

Chromosome 9 (human)
Genomic location for IFNB1

Genomic location for IFNB1

Band9p21.3Start21,077,105 bp[1]
End21,077,963 bp[1]









RNA expression pattern
PBB GE IFNB1 208173 at fs.png
More reference expression data






Orthologs
SpeciesHumanMouse
Entrez

3456

15977

Ensembl

ENSG00000171855

ENSMUSG00000048806

UniProt

P01574

P01575

RefSeq (mRNA)

NM_002176

NM_010510

RefSeq (protein)

NP_002167

NP_034640

Location (UCSC)Chr 9: 21.08 – 21.08 MbChr 4: 88.52 – 88.52 Mb

PubMed search		[3][4]
Wikidata


View/Edit HumanView/Edit Mouse

Interferon beta is a protein that in humans is encoded by the IFNB1 gene.[5] The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties.[6]


Interferon beta 1a (tradenames: Avonex and Rebif) and Interferon beta 1b (tradenames: Betaseron/Betaferon) are used as drugs.



References[edit]




  1. ^ abc GRCh38: Ensembl release 89: ENSG00000171855 - Ensembl, May 2017


  2. ^ abc GRCm38: Ensembl release 89: ENSMUSG00000048806 - Ensembl, May 2017


  3. ^ "Human PubMed Reference:"..mw-parser-output cite.citationfont-style:inherit.mw-parser-output qquotes:"""""""'""'".mw-parser-output code.cs1-codecolor:inherit;background:inherit;border:inherit;padding:inherit.mw-parser-output .cs1-lock-free abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-lock-subscription abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registrationcolor:#555.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration spanborder-bottom:1px dotted;cursor:help.mw-parser-output .cs1-hidden-errordisplay:none;font-size:100%.mw-parser-output .cs1-visible-errorfont-size:100%.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-formatfont-size:95%.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-leftpadding-left:0.2em.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-rightpadding-right:0.2em


  4. ^ "Mouse PubMed Reference:".


  5. ^ "Entrez Gene: IFNB1 interferon, beta 1, fibroblast".


  6. ^ "IFNB1 recombinant protein".



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Further reading[edit]


.mw-parser-output .refbeginfont-size:90%;margin-bottom:0.5em.mw-parser-output .refbegin-hanging-indents>ullist-style-type:none;margin-left:0.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>ddmargin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none.mw-parser-output .refbegin-100font-size:100%


  • Biron CA, Nguyen KB, Pien GC (2002). "Innate immune responses to LCMV infections: natural killer cells and cytokines". Curr. Top. Microbiol. Immunol. 263: 7–27. doi:10.1007/978-3-642-56055-2_2. PMID 11987821.


  • Conti L, Fantuzzi L, Del Cornò M, et al. (2005). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis". Immunobiology. 209 (1–2): 99–115. doi:10.1016/j.imbio.2004.02.008. PMID 15481145.


  • Bekisz J, Schmeisser H, Hernandez J, et al. (2005). "Human interferons alpha, beta and omega". Growth Factors. 22 (4): 243–51. doi:10.1080/08977190400000833. PMID 15621727.


  • Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines". Mini Reviews in Medicinal Chemistry. 5 (12): 1093–101. doi:10.2174/138955705774933383. PMID 16375755.


  • Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes". J. Exp. Pathol. 5 (2): 69–77. PMID 1708818.


  • Flores I, Mariano TM, Pestka S (1991). "Human interferon omega (omega) binds to the alpha/beta receptor". J. Biol. Chem. 266 (30): 19875–7. PMID 1834641.


  • May LT, Sehgal PB (1985). "On the relationship between human interferon alpha 1 and beta 1 genes". J. Interferon Res. 5 (3): 521–6. PMID 2414376.


  • Francois DT, Katona IM, June CH, et al. (1988). "Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens". Clin. Immunol. Immunopathol. 48 (3): 297–306. doi:10.1016/0090-1229(88)90023-2. PMID 3135963.


  • Conradt HS, Egge H, Peter-Katalinic J, et al. (1987). "Structure of the carbohydrate moiety of human interferon-beta secreted by a recombinant Chinese hamster ovary cell line". J. Biol. Chem. 262 (30): 14600–5. PMID 3667593.


  • Blank KJ, McKernan LN, Murasko DM (1985). "Poly I:C or IFN-alpha/beta treatment inhibits macrophage induced T cell proliferation". J. Interferon Res. 5 (1): 215–21. doi:10.1089/jir.1985.5.215. PMID 3872918.


  • Derynck R, Content J, DeClercq E, et al. (1980). "Isolation and structure of a human fibroblast interferon gene". Nature. 285 (5766): 542–7. doi:10.1038/285542a0. PMID 6157094.


  • Taniguchi T, Ohno S, Fujii-Kuriyama Y, Muramatsu M (1980). "The nucleotide sequence of human fibroblast interferon cDNA". Gene. 10 (1): 11–5. doi:10.1016/0378-1119(80)90138-9. PMID 6157601.


  • Houghton M, Easton MA, Stewart AG, et al. (1981). "The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase". Nucleic Acids Res. 8 (13): 2885–94. doi:10.1093/nar/8.13.2885. PMC 324132. PMID 6159580.


  • Goeddel DV, Shepard HM, Yelverton E, et al. (1981). "Synthesis of human fibroblast interferon by E. coli". Nucleic Acids Res. 8 (18): 4057–74. doi:10.1093/nar/8.18.4057. PMC 324219. PMID 6159584.


  • Houghton M, Stewart AG, Doel SM, et al. (1981). "The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers". Nucleic Acids Res. 8 (9): 1913–31. doi:10.1093/nar/8.9.1913. PMC 324047. PMID 6159597.


  • Wetzel R (1981). "Assignment of the disulphide bonds of leukocyte interferon". Nature. 289 (5798): 606–7. doi:10.1038/289606a0. PMID 6162107.


  • Lawn RM, Adelman J, Franke AE, et al. (1981). "Human fibroblast interferon gene lacks introns". Nucleic Acids Res. 9 (5): 1045–52. doi:10.1093/nar/9.5.1045. PMC 326735. PMID 6164984.


  • Shepard HM, Leung D, Stebbing N, Goeddel DV (1982). "A single amino acid change in IFN-beta1 abolishes its antiviral activity". Nature. 294 (5841): 563–5. doi:10.1038/294563a0. PMID 6171735.


  • Content J, De Wit L, Pierard D, et al. (1982). "Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta". Proc. Natl. Acad. Sci. U.S.A. 79 (9): 2768–72. doi:10.1073/pnas.79.9.2768. PMC 346287. PMID 6178110.


  • Fiers W, Remaut E, Devos R, et al. (1983). "The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells". Philos. Trans. R. Soc. Lond. B Biol. Sci. 299 (1094): 29–38. doi:10.1098/rstb.1982.0103. PMID 6183692.


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