Template:TGFβ receptor superfamily modulators
From Wikipedia, the free encyclopedia
Jump to navigation
Jump to search
TGFβ receptor superfamily modulators
|
|---|
| Type I |
ALK1 (ACVRL1) |
Agonists: Activin (A, B, AB)
- Avotermin
BMP (10)
- Cetermin
GDF (2 (BMP9))
TGFβ (1, 2, 3)
Antibodies: Ascrinvacumab
Kinase inhibitors: K-02288
- ML-347 (LDN-193719, VU0469381)
Decoy receptors: Dalantercept
Other inhibitors: Disitertide
|
|---|
ALK2 (ACVR1A) |
Agonists: Activin (A, B, AB)
- AMH (MIS)
- Avotermin
BMP (5, 6, 7, 8A, 8B)
- Eptotermin alfa
TGFβ (1, 2, 3)
Kinase inhibitors: DMH-1
- DMH-2
- Dorsomorphin (BML-275)
- K-02288
- ML-347 (LDN-193719, VU0469381)
|
|---|
ALK3 (BMPR1A) |
Agonists: AMH (MIS)
BMP (2, 4, 5, 6, 7, 8A, 8B)
- Dibotermin alfa
- Eptotermin alfa
Kinase inhibitors: DMH-2
- Dorsomorphin (BML-275)
- K-02288
|
|---|
ALK4 (ACVR1B) |
Agonists: Activin (A, B, AB)
GDF (1, 3, 11 (BMP11))
- Myostatin (GDF8)
- Nodal
Antagonists: Inhibin (A, B)
Lefty (1, 2)
Kinase inhibitors: A 83-01
- SB-431542
- SB-505124
|
|---|
ALK5 (TGFβR1) |
Agonists: Avotermin
GDF (10 (BMP3B), 11 (BMP11))
TGFβ (1, 2, 3)
Antibodies: Fresolimumab
- Lerdelimumab
- Metelimumab
Kinase inhibitors: A 83-01
- D-4476
- GW-788388
- LY-364947
- LY-2109761
- Galunisertib (LY-2157299)
- R-268712
- RepSox (E-616452, SJN-2511)
- SB-431542
- SB-505124
- SB-525334
- SD-208
|
|---|
ALK6 (BMPR1B) |
Agonists: BMP (2, 4, 5, 6, 7, 8A, 8B, 15 (GDF9B))
- Dibotermin alfa
- Eptotermin alfa
GDF (5 (BMP14), 6 (BMP13), 7 (BMP12), 9, 15)
- Radotermin
Kinase inhibitors: DMH-2
- Dorsomorphin (BML-275)
- K-02288
|
|---|
ALK7 (ACVR1C) |
Agonists: GDF (1, 3, 11 (BMP11))
- Nodal
Antagonists: Lefty (1, 2)
Kinase inhibitors: A 83-01
- SB-431542
- SB-505124
|
|---|
|
|---|
| Type II |
| TGFβR2 |
Agonists: Avotermin
GDF (10 (BMP3B))
TGFβ (1, 2, 3)
Antibodies: Fresolimumab
- Lerdelimumab
- Metelimumab
Kinase inhibitors: DMH-2
- LY-364947
|
|---|
| BMPR2 |
Agonists: BMP (2, 4, 6, 7, 10)
- Dibotermin alfa
- Eptotermin alfa
GDF (2 (BMP9), 5 (BMP14), 6 (BMP13), 7 (BMP12))
- Radotermin
Antagonists: Inhibin (A, B)
|
|---|
ACVR2A (ACVR2) |
Agonists: Activin (A, B, AB)
BMP (2, 4, 5, 6, 7, 8A, 8B, 15 (GDF9B))
- Dibotermin alfa
- Eptotermin alfa
GDF (1, 3, 5 (BMP14), 6 (BMP13), 7 (BMP12), 9, 11 (BMP11), 15)
- Myostatin (GDF8)
- Nodal
- Radotermin
Antagonists: Inhibin (A, B)
Lefty (1, 2)
Decoy receptors: Sotatercept
|
|---|
| ACVR2B |
Agonists: Activin (A, B, AB)
BMP (2, 4, 6, 7)
- Dibotermin alfa
- Eptotermin alfa
GDF (1, 3, 5 (BMP14), 6 (BMP13), 7 (BMP12))
- Myostatin (GDF8)
- Nodal
- Osteogenin (BMP3, BMP3A)
- Radotermin
Antagonists: Inhibin (A, B)
Lefty (1, 2)
Decoy receptors: Ramatercept
|
|---|
AMHR2 (AMHR) |
|
|---|
|
|---|
| Type III |
TGFβR3 (β-glycan) |
Ligands: Avotermin
Inhibin (A, B)
TGFβ (1, 2, 3)
|
|---|
|
|---|
| Unsorted |
Endogenous antagonists/inhibitors: BAMBI
- Cerberus (CER1)
- Chordin
- DAN (PARN)
- Decorin
- Follistatin
- Gremlin (Drm)
- LTBP1
- Noggin
- TGIF
- Thrombospondin 1 (THBS1)
- Tomoregulin 1
Antibodies: Stamulumab (against myostatin)
TRC105 (against endoglin)
|
|---|
- See also
- Receptor/signaling modulators
- Signaling peptide/protein receptor modulators
- Growth factor receptor modulators
- Cytokine receptor modulators
|
Initial visibility: currently defaults to autocollapse
To set this template's initial visibility, the |state= parameter may be used:
|state=collapsed: state=collapsed to show the template collapsed, i.e., hidden apart from its title bar
|state=expanded: state=expanded to show the template expanded, i.e., fully visible
|state=autocollapse: TGFβ receptor superfamily modulators
- shows the template collapsed to the title bar if there is a navbar, a sidebar, or some other table on the page with the collapsible attribute
- shows the template in its expanded state if there are no other collapsible items on the page
If the |state= parameter in the template on this page is not set, the template's initial visibility is taken from the |default= parameter in the Collapsible option template. For the template on this page, that currently evaluates to autocollapse.
Categories:
- Drug templates by receptor, channel, or pump
Navigation menu
Personal tools
- Not logged in
- Talk
- Contributions
- Create account
- Log in
Navigation
- Main page
- Contents
- Featured content
- Current events
- Random article
- Donate to Wikipedia
- Wikipedia store
Interaction
- Help
- About Wikipedia
- Community portal
- Recent changes
- Contact page
Tools
- What links here
- Related changes
- Upload file
- Special pages
- Permanent link
- Page information
- Wikidata item
(window.RLQ=window.RLQ||).push(function()mw.config.set("wgPageParseReport":"limitreport":"cputime":"0.132","walltime":"0.151","ppvisitednodes":"value":917,"limit":1000000,"ppgeneratednodes":"value":0,"limit":1500000,"postexpandincludesize":"value":54871,"limit":2097152,"templateargumentsize":"value":1023,"limit":2097152,"expansiondepth":"value":7,"limit":40,"expensivefunctioncount":"value":0,"limit":500,"unstrip-depth":"value":0,"limit":20,"unstrip-size":"value":832,"limit":5000000,"entityaccesscount":"value":0,"limit":400,"timingprofile":["134.24% 103.825 4 Template:Navbox","100.00% 77.340 1 -total"," 35.13% 27.172 23 Template:Abbr"," 13.06% 10.099 1 Template:Collapsible_option"," 3.39% 2.622 6 Template:Para"," 2.88% 2.230 1 Template:Template_other"," 2.26% 1.749 3 Template:Big"],"scribunto":"limitreport-timeusage":"value":"0.033","limit":"10.000","limitreport-memusage":"value":1676204,"limit":52428800,"cachereport":"origin":"mw1270","timestamp":"20181011051416","ttl":1900800,"transientcontent":false);mw.config.set("wgBackendResponseTime":79,"wgHostname":"mw1328"););
Clash Royale CLAN TAG