Template:Signaling peptide/protein receptor modulators
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Signaling peptide/protein receptor modulators
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Adiponectin |
AdipoR1 |
Agonists: Peptide: Adiponectin
- ADP-355
ADP-399; Non-peptide: AdipoRon
- (–)-Arctigenin
- Arctiin
- Gramine
- Matairesinol
Antagonists: Peptide: ADP-400
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AdipoR2 |
Agonists: Peptide: Adiponectin
- ADP-355
ADP-399; Non-peptide: AdipoRon
- Deoxyschizandrin
- Parthenolide
- Syringing
- Taxifoliol
Antagonists: Peptide: ADP-400
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Angiotensin |
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Bradykinin |
Agonists: Bradykinin
- Kallidin
Antagonists: FR-173657
- Icatibant
- LF22-0542
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CGRP |
Agonists: Amylin
- CGRP
- Pramlintide
Antagonists: Atogepant
- BI 44370 TA
- CGRP (8-37)
- MK-3207
- Olcegepant
- Rimegepant
- SB-268262
- Telcagepant
- Ubrogepant
Antibodies: Eptinezumab
- Erenumab
- Fremanezumab
- Galcanezumab
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Cholecystokinin |
CCKA |
Agonists: Cholecystokinin
Antagonists: Amiglumide
- Asperlicin
- Devazepide
- Dexloxiglumide
- Lintitript
- Lorglumide
- Loxiglumide
- Pranazepide
- Proglumide
- Tarazepide
- Tomoglumide
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CCKB |
Agonists: Cholecystokinin
- CCK-4
- Gastrin
- Pentagastrin (CCK-5)
Antagonists: Ceclazepide
- CI-988 (PD-134308)
- Itriglumide
- L-365,360
- Netazepide
- Proglumide
- Spiroglumide
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Unsorted |
Antagonists: Nastorazepide
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CRH |
CRF1 |
Agonists: Cortagine
- Corticorelin
- Corticotropin releasing hormone
- Sauvagine
- Stressin I
- Urocortin
Antagonists: Antalarmin
- Astressin-B
- CP-154,526
- Emicerfont
- Hypericin
- LWH-234
- NBI-27914
- NBI-74788
- Pexacerfont
- R-121919
- TS-041
- Verucerfont
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CRF2 |
Agonists: Corticorelin
- Corticotropin releasing hormone
- Sauvagine
- Urocortin
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Cytokine |
See here instead. |
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Endothelin |
Agonists: Endothelin 1
- Endothelin 2
- Endothelin 3
- IRL-1620
Antagonists: A-192621
- ACT-132577
- Ambrisentan
- Aprocitentan
- Atrasentan
- Avosentan
- Bosentan
- BQ-123
- BQ-788
- Clazosentan
- Darusentan
- Edonentan
- Enrasentan
- Fandosentan
- Feloprentan
- Macitentan
- Nebentan
- Sitaxentan
- Sparsentan
- Tezosentan
- Zibotentan
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Galanin |
GAL1 |
Agonists: Galanin
- Galanin (1-15)
- Galanin-like peptide
- Galmic
- Galnon
- NAX 810-2
Antagonists: C7
- Dithiepine-1,1,4,4-tetroxide
- Galantide (M15)
- M32
- M35
- M40
- SCH-202596
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GAL2 |
Agonists: Galanin
- Galanin (1-15)
- Galanin (2-11)
- Galanin-like peptide
- Galmic
- Galnon
- J18
- NAX 810-2
Antagonists: C7
- Galantide (M15)
- M32
- M35
- M40
- M871
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GAL3 |
Agonists: Galanin
- Galanin (1-15)
- Galmic
- Galnon
Antagonists: C7
- Galantide (M15)
- GalR3ant
- HT-2157
- M32
- M35
- M40
- SNAP-37889
- SNAP-398299
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Ghrelin/GHS |
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GH |
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GHRH |
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GLP |
GLP-1 |
Agonists: Albiglutide
- Beinaglutide
- Dulaglutide
- Efpeglenatide
- Exenatide
- GLP-1
- Langlenatide
- Liraglutide
- Lixisenatide
- Oxyntomodulin
- Pegapamodutide
- Semaglutide
- Taspoglutide
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GLP-2 |
Agonists: Apraglutide
- Elsiglutide
- Glepaglutide
- GLP-2
- Teduglutide
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Others |
Propeptides: Preproglucagon
- Proglucagon
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Glucagon |
Agonists: Dasiglucagon
- Glucagon
- Oxyntomodulin
Antagonists: Adomeglivant
- L-168,049
- LGD-6972
Propeptides: Preproglucagon
- Proglucagon
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GnRH |
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Gonadotropin |
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Growth factor |
See here instead. |
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Insulin |
Agonists: Chaetochromin (4548-G05)
- Insulin-like growth factor 1
- Insulin-like growth factor 2
- Insulin
- Insulin aspart
- Insulin degludec
- Insulin detemir
- Insulin glargine
- Insulin glulisine
- Insulin lispro
- Mecasermin
- Mecasermin rinfabate
Antagonists: BMS-754807
- S661
- S961
Kinase inhibitors: Linsitinib
Antibodies: Xentuzumab (against IGF-1 and IGF-2)
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Kisspeptin |
Agonists: Kisspeptin
- Kisspeptin-10
Antagonists: Kisspeptin-234
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Leptin |
Agonists: Leptin
- Metreleptin
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MCH |
MCH1 |
Agonists: Melanin concentrating hormone
Antagonists: ATC-0065
- ATC-0175
- GW-803430
- NGD-4715
- SNAP-7941
- SNAP-94847
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MCH2 |
Agonists: Melanin concentrating hormone
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Melanocortin |
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Neuropeptide FF |
Agonists: Neuropeptide AF
- Neuropeptide FF
- Neuropeptide SF (RFRP-1)
- Neuropeptide VF (RFRP-3)
Antagonists: BIBP-3226
- RF9
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Neuropeptide S |
Antagonists: ML-154
- SHA-68
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Neuropeptide Y |
Y1 |
Agonists: Neuropeptide Y
- Peptide YY
Antagonists: BIBO-3304
- BIBP-3226
- BVD-10
- GR-231118
- PD-160170
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Y2 |
Agonists: 2-Thiouridine 5'-triphosphate
- Neuropeptide Y
- Neuropeptide Y (13-36)
- Peptide YY
- Peptide YY (3-36)
Antagonists: BIIE-0246
- JNJ-5207787
- SF-11
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Y4 |
Agonists: GR-231118
- Neuropeptide Y
- Pancreatic polypeptide
- Peptide YY
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Y5 |
Agonists: BWX-46
- Neuropeptide Y
- Peptide YY
Antagonists: CGP-71683
- FMS-586
- L-152,804
- Lu AA-33810
- MK-0557
- NTNCB
- Velneperit (S-2367)
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Neurotensin |
NTS1 |
Agonists: Neurotensin
- Neuromedin N
Antagonists: Meclinertant
- SR-142948
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NTS2 |
Antagonists: Levocabastine
- SR-142948
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Opioid |
See here instead. |
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Orexin |
OX1 |
Antagonists: ACT-335827
- ACT-462206
- Almorexant
- Filorexant
- Lemborexant
- Nemorexant
- RTIOX-276
- SB-334867
- SB-408124
- SB-649868
- Suvorexant
- TCS-1102
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OX2 |
Agonists: Orexin (A, B)
- SB-668875
Antagonists: ACT-335827
- ACT-462206
- Almorexant
- EMPA
- Filorexant
- JNJ-10397049
- Lemborexant
- MK-1064
- SB-649868
- Seltorexant
- Suvorexant
- TCS-1102
- TCS-OX2-29
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Oxytocin |
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Prolactin |
Agonists: Growth hormone
- Human placental lactogen
- Placental growth hormone (growth hormone variant)
- Prolactin
- S179D-hPRL
- Somatotropin
Antagonists: Δ1–9-G129R-hPRL
- Δ1–14-G129R-hPRL
- G120K-hGH
- G129R-hPRL
Prolactin modulators: Prolactin inhibitors: D2 receptor agonists (e.g., bromocriptine, cabergoline); Prolactin releasers: D2 receptor antagonists (e.g., domperidone, metoclopramide, risperidone)
Estrogens (e.g., estradiol)
Progestogens (e.g., progesterone)
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PTH |
Agonists: Abaloparatide
- Parathyroid hormone
- Parathyroid hormone-related protein (PTHrP)
- Semparatide
- Teriparatide
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Relaxin |
Agonists: Insulin-like factor 3
Relaxin (1, 2, 3)
- Serelaxin
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Somatostatin |
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Tachykinin |
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TRH |
Agonists: Azetirelin
- Fertirelin
- Montirelin
- Orotirelin
- Posatirelin
- Protirelin
- Rovatirelin
- Taltirelin
- TRH (TRF)
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TSH |
Agonists: Thyrotropin alfa
- TSH (thyrotropin)
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Vasopressin |
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VIP/PACAP
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VIPR1 |
Agonists: Peptide: Bay 55-9837
- LBT-3393
- PACAP
- VIP
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VIPR2 |
Agonists: Peptide: LBT-3627
- PACAP
- VIP
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PAC1 |
Agonists: PACAP
- PACAP (1-27)
- PACAP (1-38)
Antagonists: PACAP (6-38)
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Unsorted |
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Others |
Endogenous: Adrenomedullin
- Apelin
- Asprosin
- Bombesin
- Calcitonin
- Carnosine
- CART
- CLIP
- DSIP
- Enteroglucagon
- Formyl peptide
- GALP
- GIP
- GRP
Integrin ligands (collagens, fibrinogen, fibronectin, laminins, ICAM-1, ICAM-2, osteopontin, VCAM-1, vitronectin)
- Kininogens
- Motilin
Natriuretic peptides (ANP, BNP, CNP, urodilatin)
- Nesfatin-1
- Neuromedin B
- Neuromedin N
- Neuromedin S
- Neuromedin U
- Obestatin
- Osteocalcin
- Resistin
- Secretin
- Thymopoietin
- Thymosins
- Thymulin
- Urotensin-II
- VGF
Exogenous: Lifitegrast (LFA-1 antagonist)
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- See also
- Receptor/signaling modulators
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- Drug templates by receptor, channel, or pump
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