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Pakritinib







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Pakritinib


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Pakritinib

Pacritinib skeletal.svg
Klinički podaci
Drugs.com
Monografija
Identifikatori
ATC kod
None
PubChem
CID 46216796
ChemSpider
28518965 ДаY
ChEMBL
CHEMBL2035187 ДаY
Sinonimi
SB1518
Hemijski podaci
Formula
C28H32N4O3
Molarna masa
472,579





Pakritinib je organsko jedinjenje, koje sadrži 28 atoma ugljenika i ima molekulsku masu od 472,579 Da.




Садржај





  • 1 Osobine


  • 2 Reference


  • 3 Literatura


  • 4 Spoljašnje veze




Osobine[уреди]
















OsobinaVrednost
Broj akceptora vodonika7
Broj donora vodonika1
Broj rotacionih veza4

Particioni koeficijent[1] (ALogP)
4,5

Rastvorljivost[2] (logS, log(mol/L))
-6,8

Polarna površina[3] (PSA, Å2)
68,7


Reference[уреди]




  1. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 


  2. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 


  3. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 



Literatura[уреди]


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  • Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803. 


  • Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799. 



Spoljašnje veze[уреди]





  • Pacritinib


Преузето из „https://sr.wikipedia.org/w/index.php?title=Pakritinib&oldid=12329008“





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