Interleukin-28 receptor
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| interleukin 28 receptor, alpha (interferon, lambda receptor) |
|---|
| Identifiers |
|---|
| Symbol |
IL28RA
|
|---|
| Alt. symbols |
CRF2/12, IFNLR, IL-28R1 |
|---|
| Entrez |
163702
|
|---|
| HUGO |
18584
|
|---|
| OMIM |
607404
|
|---|
| RefSeq |
NM_170743
|
|---|
| UniProt |
Q8IU57
|
|---|
| Other data |
|---|
| Locus |
Chr. 1 p36.11
|
|---|
| interleukin 10 receptor, beta |
|---|
| Identifiers |
|---|
| Symbol |
IL10RB
|
|---|
| Alt. symbols |
CRFB4, D21S58, D21S66 |
|---|
| Entrez |
3588
|
|---|
| HUGO |
5965
|
|---|
| OMIM |
123889
|
|---|
| RefSeq |
NM_000628
|
|---|
| UniProt |
Q08334
|
|---|
| Other data |
|---|
| Locus |
Chr. 21 q22.1-22.2
|
|---|
Interleukin-28 receptor is a type II cytokine receptor. It binds interleukin-28. It consists of an α and shares a common β subunit with the interleukin-10 receptor.[1][2]
References[edit]
^ Kotenko SV, Gallagher G, Baurin VV, Lewis-Antes A, Shen M, Shah NK, Langer JA, Sheikh F, Dickensheets H, Donnelly RP (2003). "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex". Nat. Immunol. 4 (1): 69–77. doi:10.1038/ni875. PMID 12483210..mw-parser-output cite.citationfont-style:inherit.mw-parser-output qquotes:"""""""'""'".mw-parser-output code.cs1-codecolor:inherit;background:inherit;border:inherit;padding:inherit.mw-parser-output .cs1-lock-free abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-lock-subscription abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registrationcolor:#555.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration spanborder-bottom:1px dotted;cursor:help.mw-parser-output .cs1-hidden-errordisplay:none;font-size:100%.mw-parser-output .cs1-visible-errorfont-size:100%.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-formatfont-size:95%.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-leftpadding-left:0.2em.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-rightpadding-right:0.2em
^ Sheppard P, Kindsvogel W, Xu W, Henderson K, Schlutsmeyer S, Whitmore TE, Kuestner R, Garrigues U, Birks C, Roraback J, Ostrander C, Dong D, Shin J, Presnell S, Fox B, Haldeman B, Cooper E, Taft D, Gilbert T, Grant FJ, Tackett M, Krivan W, McKnight G, Clegg C, Foster D, Klucher KM (2003). "IL-28, IL-29 and their class II cytokine receptor IL-28R". Nat. Immunol. 4 (1): 63–8. doi:10.1038/ni873. PMID 12469119.
External links[edit]
Receptors,+Interleukin-28 at the US National Library of Medicine Medical Subject Headings (MeSH)
Cytokine receptors
|
|---|
Chemokine receptor
(GPCRs) |
| CC |
CCR1 / CCRL1
- CCR2
- CCRL2
- CCR3
- CCR4
- CCR5
- CCR6
- CCR7
- CCR8
- CCR9
- CCR10
|
|---|
| CXC |
IL-8
- CXCR3
- CXCR4
- CXCR5
- CXCR6
- CXCR7
|
|---|
| Other |
|
|---|
|
|---|
| TNF receptor |
| 1-10 |
TNFR1 (TNFRSF1A)
TNFR2 (TNFRSF1B)
LTBR (TNFRSF3)
CD134 (TNFRSF4)
CD40 (TNFRSF5)
Fas receptor (TNFRSF6)
DcR3 (TNFRSF6B)
CD27 (TNFRSF7)
CD30 (TNFRSF8)
CD137 (TNFRSF9)
|
|---|
| 11-20 |
DR4 (TNFRSF10A)
DR5 (TNFRSF10B)
DcR1 (TNFRSF10C)
DcR2 (TNFRSF10D)
RANK (TNFRSF11A)
Osteoprotegerin (TNFRSF11B)
TweakR (TNFRSF12A)
TACI (TNFRSF13B)
BAFFR (TNFRSF13C)
HVEM (TNFRSF14)
NGFR (TNFRSF16)
BCMA (TNFRSF17)
GITR (TNFRSF18)
TAJ/TROY (TNFRSF19)
|
|---|
| 21-27 |
DR6 (TNFRSF21)
DR3 (TNFRSF25)
EDA2R (TNFRSF27)
|
|---|
|
|---|
| JAK-STAT |
| Type I |
| γ-chain |
Interleukin receptors
IL2R / IL2RA/IL2RB / IL15R
IL4R / IL13R / IL13RA1 / IL13RA2
IL7R / IL7RA
- IL9R
- IL21R
|
|---|
| β-chain |
Interleukin receptors
- GM-CSF
|
|---|
| gp130 |
Interleukin receptors
- OSMR
- LIFR
- CNTFR
|
|---|
| IL12RB1 |
Interleukin receptors
IL12R/IL12RB1/IL12RB2
- IL23R23
|
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| Other |
hormone receptor: GH
- prolactin
|
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|
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| Type II |
Interleukin receptors
IL10R / IL10RA / IL10RB / IL22R / IL22RA1 / IL22RA2
IL20R / IL20RA / IL20RB
- IL28R
Interferon receptors
-α/β / IFNAR1/IFNAR2
-γ/IFNGR1 / IFNGR2
|
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|
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| Ig superfamily |
|
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| IL 17 family |
IL17
- IL17RA
- IL17RB
- IL17RC
- IL17RD
- IL17RE
|
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| S/T |
|
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Cytokine receptor modulators
|
|---|
| Chemokine |
|
|---|
| CSF |
| Erythropoietin |
Agonists: ARA-290
- Asialo erythropoietin
- Carbamylated erythropoietin
- CNTO-530
- Darbepoetin alfa
- Epoetin alfa
- Epoetin beta
- Epoetin delta
- Epoetin epsilon
- Epoetin gamma
- Epoetin kappa
- Epoetin omega
- Epoetin theta
- Epoetin zeta
- Erythropoietin (EPO)
- Erythropoietin-Fc
- Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
- Peginesatide
- Pegol sihematide (EPO-018B)
|
|---|
| G-CSF (CSF3) |
Agonists: Filgrastim
- Granulocyte colony-stimulating factor
- Lenograstim
- Leridistim
- Lipegfilgrastim
- Nartograstim
- Pegfilgrastim
- Pegnartograstim
|
|---|
| GM-CSF (CSF2) |
Agonists: Ecogramostim
- Granulocyte macrophage colony-stimulating factor
- Milodistim
- Molgramostim
- Regramostim
- Sargramostim
Antibodies: Mavrilimumab
- MOR103
- Namilumab
|
|---|
| M-CSF (CSF1) |
Agonists: Cilmostim
- Interleukin-34
- Lanimostim
- Macrophage colony-stimulating factor
- Mirimostim
Kinase inhibitors: Agerafenib
|
|---|
| SCF (c-Kit) |
|
|---|
| Thrombopoietin |
Agonists: Eltrombopag
- Pegacaristim
- Promegapoietin
- Romiplostim
- Thrombopoietin (THPO, MGDF)
|
|---|
|
|---|
| Interferon |
| IFNAR (α/β, I) |
Agonists: Albinterferon
- Interferon alpha (interferon alfa, IFN-α)
Interferon alfa (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21)
- Interferon alfa 2a
- Interferon alfa 2b
- Interferon alfa n1
- Interferon alfacon-1
- Interferon alpha-n3
Interferon beta (IFN-β) (IFNB1, IFNB3)
- Interferon beta 1a
- Interferon beta 1b
- Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
- Interferon omega (IFN-ω, IFNW1)
- Peginterferon alfa-2a
- Peginterferon alfa-2b
Antibodies: Anifrolumab
- Faralimomab
- MEDI-545
- Rontalizumab
- Sifalimumab
Decoy receptors: Bifarcept
|
|---|
| IFNGR (γ, II) |
Agonists: Interferon gamma (IFN-γ)
- Interferon gamma 1b
Antibodies: Emapalumab
- Fontolizumab
|
|---|
| IFNLR (λ, III) |
- See IL-28R (IFNLR) here instead.
|
|---|
|
|---|
| Interleukin |
|
|---|
| TGFβ |
|
|---|
| TNF |
|
|---|
| Others |
JAK
(inhibitors)
|
| JAK1 |
- Baricitinib
- Filgotinib
- Momelotinib
- Oclacitinib
- Ruxolitinib
- Tofacitinib (tasocitinib, CP-690550)
- Upadacitinib
|
|---|
| JAK2 |
- AG-490
- Atiprimod
- AZD-1480
- Baricitinib
- CHZ868
- Cucurbitacin I (elatericin B, JSI-124)
- CYT387
- Lestaurtinib
- NSC-7908
- NSC-33994
- Pacritinib
- Ruxolitinib
- SD-1008
- Tofacitinib (tasocitinib, CP-690550)
|
|---|
| JAK3 |
- AG-490
- Cercosporamide
- TCS-21311
- Tofacitinib (tasocitinib, CP-690550)
- WHI-P 154
- ZM-39923
- ZM-449829
|
|---|
|
|---|
| Others |
Additional cytokines: Cardiotrophin 1 (CT-1)
- FMS-like tyrosine kinase 3 ligand (FLT3L)
- Leukemia/leukocyte inhibitory factor (LIF)
- Oncostatin M (OSM)
- Thymic stromal lymphopoietin (TSLP)
Additional cytokine receptor modulators: Emfilermin
- Lestaurtinib
- Midostaurin
- Quizartinib
- Sorafenib
- Sunitinib
|
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|
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- See also
- Receptor/signaling modulators
- Signaling peptide/protein receptor modulators
- Growth factor receptor modulators
|
Interleukin receptor modulators
|
|---|
| IL-1 |
Agonists: Interleukin 1 (α, β)
- Mobenakin
- Pifonakin
Antagonists: AF-12198
- Anakinra
- IL-1RA
- Isunakinra
Antibodies: Canakinumab
- Gevokizumab
- Lutikizumab
Decoy receptors: Rilonacept (IL-1 Trap)
|
|---|
| IL-2 |
Agonists: Adargileukin alfa
- Aldesleukin
- Celmoleukin
- Denileukin diftitox
- Interleukin 2
- Pegaldesleukin
- Teceleukin
- Tucotuzumab celmoleukin
Antibodies: Basiliximab
- Daclizumab (dacliximab)
- Inolimomab
|
|---|
| IL-3 |
Agonists: Daniplestim
- Interleukin 3
- Leridistim
- Milodistim
- Muplestim
- Promegapoietin
|
|---|
| IL-4 |
Agonists: Binetrakin
- Interleukin 4
- Interleukin 13
Antibodies: Dupilumab
- Pascolizumab
|
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| IL-5 |
Antibodies: Benralizumab
- Mepolizumab
- Reslizumab
Antisense oligonucleotides: TPI ASM8
|
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| IL-6 |
Agonists: Atexakin alfa
- Interleukin 6
Antibodies: ARGX-109
- Clazakizumab
- Elsilimomab
- mAb 1339
- Olokizumab
- Sarilumab
- Siltuximab
- Sirukumab
- Tocilizumab
|
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| IL-7 |
|
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| IL-8 |
- See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ) here instead.
|
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| IL-9 |
|
|---|
| IL-10 |
Agonists: Ilodecakin
- Interleukin 10 (CSIF)
|
|---|
| IL-11 |
Agonists: Interleukin 11 (AGIF)
- Oprelvekin
|
|---|
| IL-12 |
Agonists: Edodekin alfa
- Interleukin 12
Antibodies: Briakinumab
- Ustekinumab
|
|---|
| IL-13 |
Agonists: Binetrakin
- Cintredekin besudotox
- Interleukin 4
- Interleukin 13
Antibodies: Anrukinzumab
- Lebrikizumab
- Tralokinumab
|
|---|
| IL-15 |
Agonists: ALT-803
- Interleukin 15
|
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| IL-17 |
Agonists: Interleukin 17 (A, B, C, D, E (interleukin 25), F)
Antibodies: Brodalumab
- Ixekizumab
- Perakizumab
- Remtolumab
- Secukinumab
- Vunakizumab
|
|---|
| IL-18 |
Agonists: Iboctadekin
- Interleukin 18
- Interleukin 37
- Tadekinig
|
|---|
| IL-20 |
Agonists: Interleukin 19
- Interleukin 20
- Interleukin 24
Antibodies: Fletikumab (against IL-20)
|
|---|
| IL-21 |
Agonists: Denenicokin
- Interleukin 21
Antibodies: NNC0114-0005
- NNC0114-0006
|
|---|
| IL-22 |
Antibodies: Fezakinumab (against IL-22)
|
|---|
| IL-23 |
Agonists: Interleukin 23 (SGRF)
Antibodies: Brazikumab
- Briakinumab
- Guselkumab
- Tildrakizumab
- Ustekinumab
|
|---|
| IL-27 |
Agonists: Interleukin 27 (interleukin 30)
|
|---|
| IL-28 |
Agonists: Interferon λ4 (IFN-λ4)
Interleukin 28 (A (IFN-λ2), B (IFN-λ3))
- Interleukin-29 (IFN-λ1)
|
|---|
| IL-31 |
|
|---|
| IL1RL1 |
|
|---|
| IL1RL2 |
Agonists: Interleukin 36 (α, β, γ)
- Interleukin 38
|
|---|
| Others |
| JAK |
|
|---|
| Others |
- Interleukin 14 (taxilin alpha, HMW-BCGF)
Interleukin 16 (signals through CD4)
Interleukin 24 (signals through IL-22Rα1/IL-20Rβ heterodimer)
Interleukin 26 (signals through IL-20Rα/IL-10Rβ heterodimer)
- Interleukin 32
Interleukin 34 (signals through M-CSFR/CSF1R)
- Interleukin 35
Unsorted: Efavaleukin alfa
- Efineptakin alfa
|
|---|
|
|---|
- See also
- Receptor/signaling modulators
- Signaling peptide/protein receptor modulators
- Cytokine receptor modulators
|
Categories:
- Genes on human chromosome 1
- Genes on human chromosome 21
- Type II cytokine receptors
- Membrane protein stubs
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