Promegapoietin
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Promegapoietin is a drug given during chemotherapy to increase blood cell regeneration. It is a colony-stimulating factor that stimulates megakaryocyte production.[1][2]
It functions by stimulating ligands for interleukin 3 and c-Mpl.[3]
References[edit]
^ Kratz-Albers K, Scheding S, Möhle R, Bühring H, Baum C, Mc Kearn J, Büchner T, Kanz L, Brugger W (2000). "Effective ex vivo generation of megakaryocytic cells from mobilized peripheral blood CD34(+) cells with stem cell factor and promegapoietin". Exp Hematol. 28 (3): 335–46. doi:10.1016/S0301-472X(99)00152-6. PMID 10720698..mw-parser-output cite.citationfont-style:inherit.mw-parser-output qquotes:"""""""'""'".mw-parser-output code.cs1-codecolor:inherit;background:inherit;border:inherit;padding:inherit.mw-parser-output .cs1-lock-free abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-lock-subscription abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registrationcolor:#555.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration spanborder-bottom:1px dotted;cursor:help.mw-parser-output .cs1-hidden-errordisplay:none;font-size:100%.mw-parser-output .cs1-visible-errorfont-size:100%.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-formatfont-size:95%.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-leftpadding-left:0.2em.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-rightpadding-right:0.2em
^ Definition of promegapoietin - NCI Dictionary of Cancer Terms
^ Doshi P, Giri J, Abegg A, Favara J, Huynh M, Kahn L, Minnerly J, Pegg L, Villani-Price D, Siegel N, Staten N, Thomas J, McKearn J, Smith W (2001). "Promegapoietin, a family of chimeric growth factors, supports megakaryocyte development through activation of IL-3 and c-Mpl ligand signaling pathways". Exp Hematol. 29 (10): 1177–84. doi:10.1016/S0301-472X(01)00694-4. PMID 11602319.
External links[edit]
promegapoietin-1a at the US National Library of Medicine Medical Subject Headings (MeSH)
Cytokine receptor modulators
|
|---|
| Chemokine |
|
|---|
| CSF |
| Erythropoietin |
Agonists: ARA-290
- Asialo erythropoietin
- Carbamylated erythropoietin
- CNTO-530
- Darbepoetin alfa
- Epoetin alfa
- Epoetin beta
- Epoetin delta
- Epoetin epsilon
- Epoetin gamma
- Epoetin kappa
- Epoetin omega
- Epoetin theta
- Epoetin zeta
- Erythropoietin (EPO)
- Erythropoietin-Fc
- Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
- Peginesatide
- Pegol sihematide (EPO-018B)
|
|---|
| G-CSF (CSF3) |
Agonists: Filgrastim
- Granulocyte colony-stimulating factor
- Lenograstim
- Leridistim
- Lipegfilgrastim
- Nartograstim
- Pegfilgrastim
- Pegnartograstim
|
|---|
| GM-CSF (CSF2) |
Agonists: Ecogramostim
- Granulocyte macrophage colony-stimulating factor
- Milodistim
- Molgramostim
- Regramostim
- Sargramostim
Antibodies: Mavrilimumab
- MOR103
- Namilumab
|
|---|
| M-CSF (CSF1) |
Agonists: Cilmostim
- Interleukin-34
- Lanimostim
- Macrophage colony-stimulating factor
- Mirimostim
Kinase inhibitors: Agerafenib
|
|---|
| SCF (c-Kit) |
|
|---|
| Thrombopoietin |
Agonists: Eltrombopag
- Pegacaristim
- Promegapoietin
- Romiplostim
- Thrombopoietin (THPO, MGDF)
|
|---|
|
|---|
| Interferon |
| IFNAR (α/β, I) |
Agonists: Albinterferon
- Interferon alpha (interferon alfa, IFN-α)
Interferon alfa (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21)
- Interferon alfa 2a
- Interferon alfa 2b
- Interferon alfa n1
- Interferon alfacon-1
- Interferon alpha-n3
Interferon beta (IFN-β) (IFNB1, IFNB3)
- Interferon beta 1a
- Interferon beta 1b
- Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
- Interferon omega (IFN-ω, IFNW1)
- Peginterferon alfa-2a
- Peginterferon alfa-2b
Antibodies: Anifrolumab
- Faralimomab
- MEDI-545
- Rontalizumab
- Sifalimumab
Decoy receptors: Bifarcept
|
|---|
| IFNGR (γ, II) |
Agonists: Interferon gamma (IFN-γ)
- Interferon gamma 1b
Antibodies: Emapalumab
- Fontolizumab
|
|---|
| IFNLR (λ, III) |
- See IL-28R (IFNLR) here instead.
|
|---|
|
|---|
| Interleukin |
|
|---|
| TGFβ |
|
|---|
| TNF |
|
|---|
| Others |
JAK
(inhibitors)
|
| JAK1 |
- Baricitinib
- Filgotinib
- Momelotinib
- Oclacitinib
- Ruxolitinib
- Tofacitinib (tasocitinib, CP-690550)
- Upadacitinib
|
|---|
| JAK2 |
- AG-490
- Atiprimod
- AZD-1480
- Baricitinib
- CHZ868
- Cucurbitacin I (elatericin B, JSI-124)
- CYT387
- Lestaurtinib
- NSC-7908
- NSC-33994
- Pacritinib
- Ruxolitinib
- SD-1008
- Tofacitinib (tasocitinib, CP-690550)
|
|---|
| JAK3 |
- AG-490
- Cercosporamide
- TCS-21311
- Tofacitinib (tasocitinib, CP-690550)
- WHI-P 154
- ZM-39923
- ZM-449829
|
|---|
|
|---|
| Others |
Additional cytokines: Cardiotrophin 1 (CT-1)
- FMS-like tyrosine kinase 3 ligand (FLT3L)
- Leukemia/leukocyte inhibitory factor (LIF)
- Oncostatin M (OSM)
- Thymic stromal lymphopoietin (TSLP)
Additional cytokine receptor modulators: Emfilermin
- Lestaurtinib
- Midostaurin
- Quizartinib
- Sorafenib
- Sunitinib
|
|---|
|
|---|
- See also
- Receptor/signaling modulators
- Signaling peptide/protein receptor modulators
- Growth factor receptor modulators
|
Interleukin receptor modulators
|
|---|
| IL-1 |
Agonists: Interleukin 1 (α, β)
- Mobenakin
- Pifonakin
Antagonists: AF-12198
- Anakinra
- IL-1RA
- Isunakinra
Antibodies: Canakinumab
- Gevokizumab
- Lutikizumab
Decoy receptors: Rilonacept (IL-1 Trap)
|
|---|
| IL-2 |
Agonists: Adargileukin alfa
- Aldesleukin
- Celmoleukin
- Denileukin diftitox
- Interleukin 2
- Pegaldesleukin
- Teceleukin
- Tucotuzumab celmoleukin
Antibodies: Basiliximab
- Daclizumab (dacliximab)
- Inolimomab
|
|---|
| IL-3 |
Agonists: Daniplestim
- Interleukin 3
- Leridistim
- Milodistim
- Muplestim
- Promegapoietin
|
|---|
| IL-4 |
Agonists: Binetrakin
- Interleukin 4
- Interleukin 13
Antibodies: Dupilumab
- Pascolizumab
|
|---|
| IL-5 |
Antibodies: Benralizumab
- Mepolizumab
- Reslizumab
Antisense oligonucleotides: TPI ASM8
|
|---|
| IL-6 |
Agonists: Atexakin alfa
- Interleukin 6
Antibodies: ARGX-109
- Clazakizumab
- Elsilimomab
- mAb 1339
- Olokizumab
- Sarilumab
- Siltuximab
- Sirukumab
- Tocilizumab
|
|---|
| IL-7 |
|
|---|
| IL-8 |
- See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ) here instead.
|
|---|
| IL-9 |
|
|---|
| IL-10 |
Agonists: Ilodecakin
- Interleukin 10 (CSIF)
|
|---|
| IL-11 |
Agonists: Interleukin 11 (AGIF)
- Oprelvekin
|
|---|
| IL-12 |
Agonists: Edodekin alfa
- Interleukin 12
Antibodies: Briakinumab
- Ustekinumab
|
|---|
| IL-13 |
Agonists: Binetrakin
- Cintredekin besudotox
- Interleukin 4
- Interleukin 13
Antibodies: Anrukinzumab
- Lebrikizumab
- Tralokinumab
|
|---|
| IL-15 |
Agonists: ALT-803
- Interleukin 15
|
|---|
| IL-17 |
Agonists: Interleukin 17 (A, B, C, D, E (interleukin 25), F)
Antibodies: Brodalumab
- Ixekizumab
- Perakizumab
- Remtolumab
- Secukinumab
- Vunakizumab
|
|---|
| IL-18 |
Agonists: Iboctadekin
- Interleukin 18
- Interleukin 37
- Tadekinig
|
|---|
| IL-20 |
Agonists: Interleukin 19
- Interleukin 20
- Interleukin 24
Antibodies: Fletikumab (against IL-20)
|
|---|
| IL-21 |
Agonists: Denenicokin
- Interleukin 21
Antibodies: NNC0114-0005
- NNC0114-0006
|
|---|
| IL-22 |
Antibodies: Fezakinumab (against IL-22)
|
|---|
| IL-23 |
Agonists: Interleukin 23 (SGRF)
Antibodies: Brazikumab
- Briakinumab
- Guselkumab
- Tildrakizumab
- Ustekinumab
|
|---|
| IL-27 |
Agonists: Interleukin 27 (interleukin 30)
|
|---|
| IL-28 |
Agonists: Interferon λ4 (IFN-λ4)
Interleukin 28 (A (IFN-λ2), B (IFN-λ3))
- Interleukin-29 (IFN-λ1)
|
|---|
| IL-31 |
|
|---|
| IL1RL1 |
|
|---|
| IL1RL2 |
Agonists: Interleukin 36 (α, β, γ)
- Interleukin 38
|
|---|
| Others |
| JAK |
|
|---|
| Others |
- Interleukin 14 (taxilin alpha, HMW-BCGF)
Interleukin 16 (signals through CD4)
Interleukin 24 (signals through IL-22Rα1/IL-20Rβ heterodimer)
Interleukin 26 (signals through IL-20Rα/IL-10Rβ heterodimer)
- Interleukin 32
Interleukin 34 (signals through M-CSFR/CSF1R)
- Interleukin 35
Unsorted: Efavaleukin alfa
- Efineptakin alfa
|
|---|
|
|---|
- See also
- Receptor/signaling modulators
- Signaling peptide/protein receptor modulators
- Cytokine receptor modulators
|
Categories:
- Antianemic preparations
- Cytokines
- Thrombopoietin receptor agonists
- Blood and blood forming organ drug stubs
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