IFNA5
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| IFNA5 |
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| Available structures |
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| PDB |
Human UniProt search: PDBe RCSB
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| Identifiers |
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| Aliases |
IFNA5, IFN-alpha-5, IFN-alphaG, INA5, INFA5, leIF G, interferon alpha 5 |
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| External IDs |
HomoloGene: 117697 GeneCards: IFNA5 |
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| Gene location (Human) |
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 | | Chr. |
Chromosome 9 (human)[1] |
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| | Band |
9p21.3 |
Start |
21,304,326 bp[1] |
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| End |
21,305,312 bp[1] |
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RNA expression pattern |
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 | | More reference expression data |
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| Gene ontology |
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| Molecular function |
• cytokine activity
• type I interferon receptor binding
• cytokine receptor binding
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| Cellular component |
• extracellular region
• extracellular space
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| Biological process |
• natural killer cell activation involved in immune response
• B cell differentiation
• defense response
• B cell proliferation
• blood coagulation
• positive regulation of peptidyl-serine phosphorylation of STAT protein
• humoral immune response
• adaptive immune response
• defense response to virus
• type I interferon signaling pathway
• response to exogenous dsRNA
• T cell activation involved in immune response
• innate immune response
• cytokine-mediated signaling pathway
• regulation of receptor activity
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Sources:Amigo / QuickGO
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| Orthologs |
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| Species |
Human |
Mouse |
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| Entrez |
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| Ensembl |
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| UniProt |
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| RefSeq (mRNA) |
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| RefSeq (protein) |
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| Location (UCSC) |
Chr 9: 21.3 – 21.31 Mb |
n/a |
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PubMed search |
[2] |
n/a |
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| Wikidata |
|
Interferon alpha-5 is a protein that in humans is encoded by the IFNA5 gene.[3][4]
References[edit]
^ abc GRCh38: Ensembl release 89: ENSG00000147873 - Ensembl, May 2017
^ "Human PubMed Reference:"..mw-parser-output cite.citationfont-style:inherit.mw-parser-output qquotes:"""""""'""'".mw-parser-output code.cs1-codecolor:inherit;background:inherit;border:inherit;padding:inherit.mw-parser-output .cs1-lock-free abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-lock-subscription abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registrationcolor:#555.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration spanborder-bottom:1px dotted;cursor:help.mw-parser-output .cs1-hidden-errordisplay:none;font-size:100%.mw-parser-output .cs1-visible-errorfont-size:100%.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-formatfont-size:95%.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-leftpadding-left:0.2em.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-rightpadding-right:0.2em
^ Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
^ "Entrez Gene: IFNA5 interferon, alpha 5".
Further reading[edit]
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Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246.
Goeddel DV, Leung DW, Dull TJ, et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs". Nature. 290 (5801): 20–6. doi:10.1038/290020a0. PMID 6163083.
Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. PMC 231390. PMID 8668211.
Chuntharapai A, Gibbs V, Lu J, et al. (1999). "Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2". J. Immunol. 163 (2): 766–73. PMID 10395669.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Cytokine receptor modulators
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| Chemokine |
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| CSF |
| Erythropoietin |
Agonists: ARA-290
- Asialo erythropoietin
- Carbamylated erythropoietin
- CNTO-530
- Darbepoetin alfa
- Epoetin alfa
- Epoetin beta
- Epoetin delta
- Epoetin epsilon
- Epoetin gamma
- Epoetin kappa
- Epoetin omega
- Epoetin theta
- Epoetin zeta
- Erythropoietin (EPO)
- Erythropoietin-Fc
- Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
- Peginesatide
- Pegol sihematide (EPO-018B)
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| G-CSF (CSF3) |
Agonists: Filgrastim
- Granulocyte colony-stimulating factor
- Lenograstim
- Leridistim
- Lipegfilgrastim
- Nartograstim
- Pegfilgrastim
- Pegnartograstim
|
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| GM-CSF (CSF2) |
Agonists: Ecogramostim
- Granulocyte macrophage colony-stimulating factor
- Milodistim
- Molgramostim
- Regramostim
- Sargramostim
Antibodies: Mavrilimumab
- MOR103
- Namilumab
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| M-CSF (CSF1) |
Agonists: Cilmostim
- Interleukin-34
- Lanimostim
- Macrophage colony-stimulating factor
- Mirimostim
Kinase inhibitors: Agerafenib
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| SCF (c-Kit) |
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| Thrombopoietin |
Agonists: Eltrombopag
- Pegacaristim
- Promegapoietin
- Romiplostim
- Thrombopoietin (THPO, MGDF)
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| Interferon |
| IFNAR (α/β, I) |
Agonists: Albinterferon
- Interferon alpha (interferon alfa, IFN-α)
Interferon alfa (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21)
- Interferon alfa 2a
- Interferon alfa 2b
- Interferon alfa n1
- Interferon alfacon-1
- Interferon alpha-n3
Interferon beta (IFN-β) (IFNB1, IFNB3)
- Interferon beta 1a
- Interferon beta 1b
- Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
- Interferon omega (IFN-ω, IFNW1)
- Peginterferon alfa-2a
- Peginterferon alfa-2b
Antibodies: Anifrolumab
- Faralimomab
- MEDI-545
- Rontalizumab
- Sifalimumab
Decoy receptors: Bifarcept
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| IFNGR (γ, II) |
Agonists: Interferon gamma (IFN-γ)
- Interferon gamma 1b
Antibodies: Emapalumab
- Fontolizumab
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| IFNLR (λ, III) |
- See IL-28R (IFNLR) here instead.
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| Interleukin |
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| TGFβ |
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| TNF |
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| Others |
JAK
(inhibitors)
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| JAK1 |
- Baricitinib
- Filgotinib
- Momelotinib
- Oclacitinib
- Ruxolitinib
- Tofacitinib (tasocitinib, CP-690550)
- Upadacitinib
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| JAK2 |
- AG-490
- Atiprimod
- AZD-1480
- Baricitinib
- CHZ868
- Cucurbitacin I (elatericin B, JSI-124)
- CYT387
- Lestaurtinib
- NSC-7908
- NSC-33994
- Pacritinib
- Ruxolitinib
- SD-1008
- Tofacitinib (tasocitinib, CP-690550)
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| JAK3 |
- AG-490
- Cercosporamide
- TCS-21311
- Tofacitinib (tasocitinib, CP-690550)
- WHI-P 154
- ZM-39923
- ZM-449829
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| Others |
Additional cytokines: Cardiotrophin 1 (CT-1)
- FMS-like tyrosine kinase 3 ligand (FLT3L)
- Leukemia/leukocyte inhibitory factor (LIF)
- Oncostatin M (OSM)
- Thymic stromal lymphopoietin (TSLP)
Additional cytokine receptor modulators: Emfilermin
- Lestaurtinib
- Midostaurin
- Quizartinib
- Sorafenib
- Sunitinib
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- See also
- Receptor/signaling modulators
- Signaling peptide/protein receptor modulators
- Growth factor receptor modulators
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Categories:
- Genes on human chromosome 9
- Human chromosome 9 gene stubs
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