IFNA6
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| IFNA6 |
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| Identifiers |
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| Aliases |
IFNA6, IFN-alphaK, interferon alpha 6 |
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| External IDs |
HomoloGene: 105727 GeneCards: IFNA6 |
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| Gene location (Human) |
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 | | Chr. |
Chromosome 9 (human)[1] |
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| | Band |
9p21.3 |
Start |
21,349,835 bp[1] |
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| End |
21,351,378 bp[1] |
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RNA expression pattern |
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 | | More reference expression data |
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| Gene ontology |
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| Molecular function |
• cytokine activity
• type I interferon receptor binding
• cytokine receptor binding
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| Cellular component |
• extracellular region
• extracellular space
• cellular component
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| Biological process |
• natural killer cell activation involved in immune response
• B cell differentiation
• defense response
• B cell proliferation
• blood coagulation
• positive regulation of peptidyl-serine phosphorylation of STAT protein
• humoral immune response
• adaptive immune response
• defense response to virus
• type I interferon signaling pathway
• response to exogenous dsRNA
• T cell activation involved in immune response
• cytokine-mediated signaling pathway
• innate immune response
• regulation of receptor activity
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Sources:Amigo / QuickGO
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| Orthologs |
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| Species |
Human |
Mouse |
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| Entrez |
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| Ensembl |
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| UniProt |
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| RefSeq (mRNA) |
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| RefSeq (protein) |
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| Location (UCSC) |
Chr 9: 21.35 – 21.35 Mb |
n/a |
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PubMed search |
[2] |
n/a |
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| Wikidata |
|
Interferon alpha-6 is a protein that in humans is encoded by the IFNA6 gene.[3][4]
References[edit]
^ abc GRCh38: Ensembl release 89: ENSG00000120235 - Ensembl, May 2017
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^ Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
^ "Entrez Gene: IFNA6 interferon, alpha 6".
Further reading[edit]
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Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Hardy MP, Owczarek CM, Jermiin LS, et al. (2005). "Characterization of the type I interferon locus and identification of novel genes". Genomics. 84 (2): 331–45. doi:10.1016/j.ygeno.2004.03.003. PMID 15233997.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329. ( Pt 2): 295–302. PMC 1219044. PMID 9425112.
Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. PMC 231390. PMID 8668211.
Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246.
Cytokine receptor modulators
|
|---|
| Chemokine |
|
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| CSF |
| Erythropoietin |
Agonists: ARA-290
- Asialo erythropoietin
- Carbamylated erythropoietin
- CNTO-530
- Darbepoetin alfa
- Epoetin alfa
- Epoetin beta
- Epoetin delta
- Epoetin epsilon
- Epoetin gamma
- Epoetin kappa
- Epoetin omega
- Epoetin theta
- Epoetin zeta
- Erythropoietin (EPO)
- Erythropoietin-Fc
- Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
- Peginesatide
- Pegol sihematide (EPO-018B)
|
|---|
| G-CSF (CSF3) |
Agonists: Filgrastim
- Granulocyte colony-stimulating factor
- Lenograstim
- Leridistim
- Lipegfilgrastim
- Nartograstim
- Pegfilgrastim
- Pegnartograstim
|
|---|
| GM-CSF (CSF2) |
Agonists: Ecogramostim
- Granulocyte macrophage colony-stimulating factor
- Milodistim
- Molgramostim
- Regramostim
- Sargramostim
Antibodies: Mavrilimumab
- MOR103
- Namilumab
|
|---|
| M-CSF (CSF1) |
Agonists: Cilmostim
- Interleukin-34
- Lanimostim
- Macrophage colony-stimulating factor
- Mirimostim
Kinase inhibitors: Agerafenib
|
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| SCF (c-Kit) |
|
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| Thrombopoietin |
Agonists: Eltrombopag
- Pegacaristim
- Promegapoietin
- Romiplostim
- Thrombopoietin (THPO, MGDF)
|
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|
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| Interferon |
| IFNAR (α/β, I) |
Agonists: Albinterferon
- Interferon alpha (interferon alfa, IFN-α)
Interferon alfa (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21)
- Interferon alfa 2a
- Interferon alfa 2b
- Interferon alfa n1
- Interferon alfacon-1
- Interferon alpha-n3
Interferon beta (IFN-β) (IFNB1, IFNB3)
- Interferon beta 1a
- Interferon beta 1b
- Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
- Interferon omega (IFN-ω, IFNW1)
- Peginterferon alfa-2a
- Peginterferon alfa-2b
Antibodies: Anifrolumab
- Faralimomab
- MEDI-545
- Rontalizumab
- Sifalimumab
Decoy receptors: Bifarcept
|
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| IFNGR (γ, II) |
Agonists: Interferon gamma (IFN-γ)
- Interferon gamma 1b
Antibodies: Emapalumab
- Fontolizumab
|
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| IFNLR (λ, III) |
- See IL-28R (IFNLR) here instead.
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| Interleukin |
|
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| TGFβ |
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| TNF |
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| Others |
JAK
(inhibitors)
|
| JAK1 |
- Baricitinib
- Filgotinib
- Momelotinib
- Oclacitinib
- Ruxolitinib
- Tofacitinib (tasocitinib, CP-690550)
- Upadacitinib
|
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| JAK2 |
- AG-490
- Atiprimod
- AZD-1480
- Baricitinib
- CHZ868
- Cucurbitacin I (elatericin B, JSI-124)
- CYT387
- Lestaurtinib
- NSC-7908
- NSC-33994
- Pacritinib
- Ruxolitinib
- SD-1008
- Tofacitinib (tasocitinib, CP-690550)
|
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| JAK3 |
- AG-490
- Cercosporamide
- TCS-21311
- Tofacitinib (tasocitinib, CP-690550)
- WHI-P 154
- ZM-39923
- ZM-449829
|
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|
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| Others |
Additional cytokines: Cardiotrophin 1 (CT-1)
- FMS-like tyrosine kinase 3 ligand (FLT3L)
- Leukemia/leukocyte inhibitory factor (LIF)
- Oncostatin M (OSM)
- Thymic stromal lymphopoietin (TSLP)
Additional cytokine receptor modulators: Emfilermin
- Lestaurtinib
- Midostaurin
- Quizartinib
- Sorafenib
- Sunitinib
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- See also
- Receptor/signaling modulators
- Signaling peptide/protein receptor modulators
- Growth factor receptor modulators
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Categories:
- Genes on human chromosome 9
- Human chromosome 9 gene stubs
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