Cardiotrophin 1
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Cardiotrophin 1
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| cardiotrophin 1 | |
|---|---|
| Identifiers | |
| Symbol | CTF1, CT1, CT-1 |
| Entrez | 1489 |
| HUGO | 2499 |
| OMIM | 600435 |
| RefSeq | NM_001330 |
| UniProt | Q16619 |
| Other data | |
| Locus | Chr. 16 p11.2-16p11.1 |
Cardiotrophin-1 (CT-1) is a cytokine. It is a cardiac hypertrophic factor of 21.5 kDa and a protein member of the IL-6 cytokine family.
Contents
1 Pathology
2 Mode of action
3 References
4 External links
Pathology[edit]
CT-1 is associated with the pathophysiology of heart diseases, including hypertension, myocardial infarction, valvular heart disease, and congestive heart failure.
Mode of action[edit]
The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor NF-κB DNA -binding activities.
CT-1 is highly expressed in the heart, skeletal muscle, prostate and ovary and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine. [1]
References[edit]
^ "Recombinant human Cardiotrophin 1 protein (ab9838)". www.abcam.com. Retrieved 2017-08-09..mw-parser-output cite.citationfont-style:inherit.mw-parser-output qquotes:"""""""'""'".mw-parser-output code.cs1-codecolor:inherit;background:inherit;border:inherit;padding:inherit.mw-parser-output .cs1-lock-free abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-lock-subscription abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registrationcolor:#555.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration spanborder-bottom:1px dotted;cursor:help.mw-parser-output .cs1-hidden-errordisplay:none;font-size:100%.mw-parser-output .cs1-visible-errorfont-size:100%.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-formatfont-size:95%.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-leftpadding-left:0.2em.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-rightpadding-right:0.2em
External links[edit]
cardiotrophin+1 at the US National Library of Medicine Medical Subject Headings (MeSH)
Irving, Michael (August 8, 2017). "The protein that can make your heart think you exercise". newatlas.com. Retrieved 2017-08-09.
 | This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it. |
Categories:
- Genes on human chromosome 16
- Human chromosome 16 gene stubs
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