TGF beta receptor
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transforming growth factor beta, receptor type I (activin A receptor type II-like kinase, 53kDa) |
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Identifiers |
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Symbol |
TGFBR1
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Alt. symbols |
ALK5 |
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Entrez |
7046
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HUGO |
11772
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OMIM |
190181
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RefSeq |
NM_004612
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UniProt |
P36897
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Other data |
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Locus |
Chr. 9 q22
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transforming growth factor beta, receptor type II (70/80kDa) |
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Identifiers |
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Symbol |
TGFBR2
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Alt. symbols |
MFS2 |
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Entrez |
7048
|
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HUGO |
11773
|
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OMIM |
190182
|
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RefSeq |
NM_001024847
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UniProt |
P37173
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Other data |
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Locus |
Chr. 3 p22
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transforming growth factor beta, receptor type III |
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Identifiers |
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Symbol |
TGFBR3
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Alt. symbols |
β-Glycan |
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Entrez |
7049
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HUGO |
11774
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OMIM |
600742
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RefSeq |
NM_003243
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UniProt |
Q03167
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Other data |
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Locus |
Chr. 1 p33-p32
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Transforming growth factor beta (TGFβ) receptors are single pass serine/threonine kinase receptors that belong to TGFβ receptor family. They exist in several different isoforms that can be homo- or heterodimeric.[1] The number of characterized ligands in the TGFβ superfamily far exceeds the number of known receptors, suggesting the promiscuity that exists between the ligand and receptor interactions.
TGFβ is a growth factor and cytokine involved in paracrine signalling and can be found in many different tissue types, including brain, heart, kidney, liver, bone, and testes. Over-expression of TGFβ can induce renal fibrosis, causing kidney disease, as well as diabetes, and ultimately end-stage renal disease. Recent developments have found that, using certain types of protein antagonists against TGFβ receptors, can halt and in some cases reverse the effects of renal fibrosis.
Three TGFβ superfamily receptors specific for TGFβ, the TGFβ receptors, can be distinguished by their structural and functional properties. TGFβR1 (ALK5) and TGFβR2 have similar ligand-binding affinities and can be distinguished from each other only by peptide mapping. Both TGFβR1 and TGFβR2 have a high affinity for TGFβ1 and low affinity for TGFβ2. TGFβR3 (β-glycan) has a high affinity for both homodimeric TGFβ1 and TGFβ2 and in addition the heterodimer TGF-β1.2.[2] The TGFβ receptors also bind TGFβ3.
See also[edit]
- TGFβ superfamily receptor
- TGFβ signaling pathway
- TGFβ superfamily
References[edit]
^ Doré JJ, Edens M, Garamszegi N, Leof EB (November 1998). "Heteromeric and homomeric transforming growth factor-beta receptors show distinct signaling and endocytic responses in epithelial cells". The Journal of Biological Chemistry. 273 (48): 31770–7. doi:10.1074/jbc.273.48.31770. PMID 9822641..mw-parser-output cite.citationfont-style:inherit.mw-parser-output qquotes:"""""""'""'".mw-parser-output code.cs1-codecolor:inherit;background:inherit;border:inherit;padding:inherit.mw-parser-output .cs1-lock-free abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-lock-subscription abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registrationcolor:#555.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration spanborder-bottom:1px dotted;cursor:help.mw-parser-output .cs1-hidden-errordisplay:none;font-size:100%.mw-parser-output .cs1-visible-errorfont-size:100%.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-formatfont-size:95%.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-leftpadding-left:0.2em.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-rightpadding-right:0.2em (free full text)
^ Cheifetz S, Andres JL, Massagué J (November 1988). "The transforming growth factor-beta receptor type III is a membrane proteoglycan. Domain structure of the receptor". The Journal of Biological Chemistry. 263 (32): 16984–91. PMID 2903157.
External links[edit]
TGF-beta+Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
Cell signaling: TGFβ signaling pathway
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TGF beta superfamily of ligands |
TGF beta family |
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Bone morphogenetic proteins |
- BMP2
- BMP3
- BMP4
- BMP5
- BMP6
- BMP7
- BMP8a
- BMP8b
- BMP10
- BMP15
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Growth differentiation factors |
- GDF1
- GDF2
- GDF3
- GDF5
- GDF6
- GDF7
- Myostatin/GDF8
- GDF9
- GDF10
- GDF11
- GDF15
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Other |
- Activin and inhibin
- Anti-müllerian hormone
- Nodal
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TGF beta receptors (Activin, BMP) |
TGFBR1: |
Activin type 1 receptors
- ACVRL1
BMPR1
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TGFBR2: |
Activin type 2 receptors
- AMHR2
- BMPR2
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TGFBR3: |
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Transducers/SMAD
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R-SMAD (SMAD1
- SMAD2
- SMAD3
- SMAD5
SMAD9)
I-SMAD (SMAD6
SMAD7)
- SMAD4
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Ligand inhibitors |
- Cerberus
- Chordin
- Decorin
- Follistatin
- Gremlin
- Lefty
- LTBP1
- Noggin
- PARN
- THBS1
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Coreceptors |
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Other |
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Receptors: growth factor receptors
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Type I cytokine receptor |
Nerve growth factors: Ciliary neurotrophic factor
- Erythropoietin
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Receptor protein serine/threonine kinase |
TGF pathway: TGF-beta
Activin
Bone morphogenetic protein
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Receptor tyrosine kinase |
| Nerve growth factors: high affinity Trk
| | Somatomedin
- Insulin-like growth factor 1
| ErbB/Epidermal growth factor
| |
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Tumor necrosis factor receptor |
Nerve growth factors: Low affinity/p75
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Ig superfamily |
Platelet-derived growth factor
- Stem cell factor
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Other/ungrouped |
Somatomedin
- Insulin-like growth factor 2
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Cytokine receptors
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Chemokine receptor (GPCRs) |
CC |
CCR1 / CCRL1
- CCR2
- CCRL2
- CCR3
- CCR4
- CCR5
- CCR6
- CCR7
- CCR8
- CCR9
- CCR10
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CXC |
IL-8
- CXCR3
- CXCR4
- CXCR5
- CXCR6
- CXCR7
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Other |
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TNF receptor |
1-10 |
TNFR1 (TNFRSF1A)
TNFR2 (TNFRSF1B)
LTBR (TNFRSF3)
CD134 (TNFRSF4)
CD40 (TNFRSF5)
Fas receptor (TNFRSF6)
DcR3 (TNFRSF6B)
CD27 (TNFRSF7)
CD30 (TNFRSF8)
CD137 (TNFRSF9)
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11-20 |
DR4 (TNFRSF10A)
DR5 (TNFRSF10B)
DcR1 (TNFRSF10C)
DcR2 (TNFRSF10D)
RANK (TNFRSF11A)
Osteoprotegerin (TNFRSF11B)
TweakR (TNFRSF12A)
TACI (TNFRSF13B)
BAFFR (TNFRSF13C)
HVEM (TNFRSF14)
NGFR (TNFRSF16)
BCMA (TNFRSF17)
GITR (TNFRSF18)
TAJ/TROY (TNFRSF19)
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21-27 |
DR6 (TNFRSF21)
DR3 (TNFRSF25)
EDA2R (TNFRSF27)
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JAK-STAT |
Type I |
γ-chain |
Interleukin receptors
IL2R / IL2RA/IL2RB / IL15R
IL4R / IL13R / IL13RA1 / IL13RA2
IL7R / IL7RA
- IL9R
- IL21R
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β-chain |
Interleukin receptors
- GM-CSF
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gp130 |
Interleukin receptors
- OSMR
- LIFR
- CNTFR
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IL12RB1 |
Interleukin receptors
IL12R/IL12RB1/IL12RB2
- IL23R23
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Other |
hormone receptor: GH
- prolactin
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Type II |
Interleukin receptors
IL10R / IL10RA / IL10RB / IL22R / IL22RA1 / IL22RA2
IL20R / IL20RA / IL20RB
- IL28R
Interferon receptors
-α/β / IFNAR1/IFNAR2
-γ/IFNGR1 / IFNGR2
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Ig superfamily |
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IL 17 family |
IL17
- IL17RA
- IL17RB
- IL17RC
- IL17RD
- IL17RE
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S/T |
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Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)
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Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)
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Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
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Polo kinase (EC 2.7.11.21) |
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Cyclin-dependent kinase (EC 2.7.11.22) |
- CDK1
- CDK2
- CDKL2
- CDK3
- CDK4
- CDK5
- CDKL5
- CDK6
- CDK7
- CDK8
- CDK9
- CDK10
- CDK12
- CDC2L5
- PCTK1
- PCTK2
- PCTK3
- PFTK1
- CDC2L1
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(RNA-polymerase)-subunit kinase (EC 2.7.11.23) |
- RPS6KA5
- RPS6KA4
- P70S6 kinase
- P70-S6 Kinase 1
- RPS6KB2
- RPS6KA2
- RPS6KA3
- RPS6KA1
- RPS6KC1
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Mitogen-activated protein kinase (EC 2.7.11.24) |
Extracellular signal-regulated
- MAPK1
- MAPK3
- MAPK4
- MAPK6
- MAPK7
- MAPK12
- MAPK15
C-Jun N-terminal
P38 mitogen-activated protein
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MAP3K (EC 2.7.11.25) |
MAP kinase kinase kinases
- MAP3K1
- MAP3K2
- MAP3K3
- MAP3K4
- MAP3K5
- MAP3K6
- MAP3K7
- MAP3K8
RAFs
MLKs
- MAP3K12
- MAP3K13
- MAP3K9
- MAP3K10
- MAP3K11
- MAP3K7
- ZAK
- CDC7
- MAP3K14
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Tau-protein kinase (EC 2.7.11.26) |
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(acetyl-CoA carboxylase) kinase (EC 2.7.11.27) |
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Tropomyosin kinase (EC 2.7.11.28) |
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Low-density-lipoprotein receptor kinase (EC 2.7.11.29) |
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Receptor protein serine/threonine kinase (EC 2.7.11.30) |
Bone morphogenetic protein receptors
- ACVR1
- ACVR1B
- ACVR1C
- ACVR2A
- ACVR2B
- ACVRL1
- Anti-Müllerian hormone receptor
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Dual-specificity kinases (EC 2.7.12)
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MAP2K |
- MAP2K1
- MAP2K2
- MAP2K3
- MAP2K4
- MAP2K5
- MAP2K6
- MAP2K7
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TGFβ receptor superfamily modulators
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Type I |
ALK1 (ACVRL1) |
Agonists: Activin (A, B, AB)
- Avotermin
BMP (10)
- Cetermin
GDF (2 (BMP9))
TGFβ (1, 2, 3)
Antibodies: Ascrinvacumab
Kinase inhibitors: K-02288
- ML-347 (LDN-193719, VU0469381)
Decoy receptors: Dalantercept
Other inhibitors: Disitertide
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ALK2 (ACVR1A) |
Agonists: Activin (A, B, AB)
- AMH (MIS)
- Avotermin
BMP (5, 6, 7, 8A, 8B)
- Eptotermin alfa
TGFβ (1, 2, 3)
Kinase inhibitors: DMH-1
- DMH-2
- Dorsomorphin (BML-275)
- K-02288
- ML-347 (LDN-193719, VU0469381)
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ALK3 (BMPR1A) |
Agonists: AMH (MIS)
BMP (2, 4, 5, 6, 7, 8A, 8B)
- Dibotermin alfa
- Eptotermin alfa
Kinase inhibitors: DMH-2
- Dorsomorphin (BML-275)
- K-02288
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ALK4 (ACVR1B) |
Agonists: Activin (A, B, AB)
GDF (1, 3, 11 (BMP11))
- Myostatin (GDF8)
- Nodal
Antagonists: Inhibin (A, B)
Lefty (1, 2)
Kinase inhibitors: A 83-01
- SB-431542
- SB-505124
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ALK5 (TGFβR1) |
Agonists: Avotermin
GDF (10 (BMP3B), 11 (BMP11))
TGFβ (1, 2, 3)
Antibodies: Fresolimumab
- Lerdelimumab
- Metelimumab
Kinase inhibitors: A 83-01
- D-4476
- GW-788388
- LY-364947
- LY-2109761
- Galunisertib (LY-2157299)
- R-268712
- RepSox (E-616452, SJN-2511)
- SB-431542
- SB-505124
- SB-525334
- SD-208
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ALK6 (BMPR1B) |
Agonists: BMP (2, 4, 5, 6, 7, 8A, 8B, 15 (GDF9B))
- Dibotermin alfa
- Eptotermin alfa
GDF (5 (BMP14), 6 (BMP13), 7 (BMP12), 9, 15)
- Radotermin
Kinase inhibitors: DMH-2
- Dorsomorphin (BML-275)
- K-02288
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ALK7 (ACVR1C) |
Agonists: GDF (1, 3, 11 (BMP11))
- Nodal
Antagonists: Lefty (1, 2)
Kinase inhibitors: A 83-01
- SB-431542
- SB-505124
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Type II |
TGFβR2 |
Agonists: Avotermin
GDF (10 (BMP3B))
TGFβ (1, 2, 3)
Antibodies: Fresolimumab
- Lerdelimumab
- Metelimumab
Kinase inhibitors: DMH-2
- LY-364947
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BMPR2 |
Agonists: BMP (2, 4, 6, 7, 10)
- Dibotermin alfa
- Eptotermin alfa
GDF (2 (BMP9), 5 (BMP14), 6 (BMP13), 7 (BMP12))
- Radotermin
Antagonists: Inhibin (A, B)
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ACVR2A (ACVR2) |
Agonists: Activin (A, B, AB)
BMP (2, 4, 5, 6, 7, 8A, 8B, 15 (GDF9B))
- Dibotermin alfa
- Eptotermin alfa
GDF (1, 3, 5 (BMP14), 6 (BMP13), 7 (BMP12), 9, 11 (BMP11), 15)
- Myostatin (GDF8)
- Nodal
- Radotermin
Antagonists: Inhibin (A, B)
Lefty (1, 2)
Decoy receptors: Sotatercept
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ACVR2B |
Agonists: Activin (A, B, AB)
BMP (2, 4, 6, 7)
- Dibotermin alfa
- Eptotermin alfa
GDF (1, 3, 5 (BMP14), 6 (BMP13), 7 (BMP12))
- Myostatin (GDF8)
- Nodal
- Osteogenin (BMP3, BMP3A)
- Radotermin
Antagonists: Inhibin (A, B)
Lefty (1, 2)
Decoy receptors: Ramatercept
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AMHR2 (AMHR) |
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Type III |
TGFβR3 (β-glycan) |
Ligands: Avotermin
Inhibin (A, B)
TGFβ (1, 2, 3)
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Unsorted |
Endogenous antagonists/inhibitors: BAMBI
- Cerberus (CER1)
- Chordin
- DAN (PARN)
- Decorin
- Follistatin
- Gremlin (Drm)
- LTBP1
- Noggin
- TGIF
- Thrombospondin 1 (THBS1)
- Tomoregulin 1
Antibodies: Stamulumab (against myostatin)
TRC105 (against endoglin)
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- See also
- Receptor/signaling modulators
- Signaling peptide/protein receptor modulators
- Growth factor receptor modulators
- Cytokine receptor modulators
|
Categories:
- Genes on human chromosome 9
- Genes on human chromosome 3
- Genes on human chromosome 1
- Transmembrane receptors
- TGF beta receptors
- Receptor stubs
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