Type II cytokine receptors are transmembrane proteins that are expressed on the surface of certain cells, which bind and respond to a select group of cytokines. These receptors are similar to type I cytokine receptors except they do not possess the signature sequence WSXWS that is characteristic of type I receptors.
Contents
1Structure
2Types
2.1Interferon receptors
2.2Interleukin receptors
3References
Structure[edit]
Typically type II cytokine receptors are heterodimers or multimers with a high and a low affinity component. Currently no complete structure of the extracellular domains of a type II cytokine receptor is available. These receptors are related predominantly by sequence similarities in their extracellular portions that are composed of tandem Ig-like domains. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase belonging to the Janus kinase (JAK) family.
Types[edit]
Type II cytokine receptors include those that bind type I and type II interferons, and those that bind members of the interleukin-10 family (interleukin-10, interleukin-20 and interleukin-22).[1][2]
Interferon receptors[edit]
The interferon receptor is a molecule displayed on the surface of cells which allows them to interact with the anti-viral substance interferon. The receptor is genetically coded for by number of different genes, as there are a few distinct types of interferon. Interferon receptor deficiency is a condition showing some amenability to genetic therapy.[3]
interferon-alpha/beta receptor
interferon-gamma receptor
Interferon type III receptor
Interleukin receptors[edit]
Interleukin-10 receptor
Interleukin-20 receptor
Interleukin-22 receptor
Interleukin-28 receptor
References[edit]
^Dumoutier L, Lejeune D, Hor S, Fickenscher H, Renauld JC (2003). "Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3". Biochem. J. 370 (Pt 2): 391–6. doi:10.1042/BJ20021935. PMC 1223207. PMID 12521379..mw-parser-output cite.citationfont-style:inherit.mw-parser-output qquotes:"""""""'""'".mw-parser-output code.cs1-codecolor:inherit;background:inherit;border:inherit;padding:inherit.mw-parser-output .cs1-lock-free abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-lock-subscription abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registrationcolor:#555.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration spanborder-bottom:1px dotted;cursor:help.mw-parser-output .cs1-hidden-errordisplay:none;font-size:100%.mw-parser-output .cs1-visible-errorfont-size:100%.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-formatfont-size:95%.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-leftpadding-left:0.2em.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-rightpadding-right:0.2em
^Xu W, Presnell SR, Parrish-Novak J, et al. (2001). "A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9511–6. doi:10.1073/pnas.171303198. PMC 55483. PMID 11481447.
^Reuter U, Roesler J, Thiede C, Schulz A, Classen CF, Oelschlagel U, Debatin KM, Friedrich W (2002). "Correction of complete interferon-gamma receptor 1 deficiency by bone marrow transplantation". Blood. 100 (12): 4234–5. doi:10.1182/blood-2002-02-0433. PMID 12393576.
The Dalles, Oregon From Wikipedia, the free encyclopedia Jump to navigation Jump to search This article is about the city in Oregon. For the nearby geological formation, see Celilo Falls. For other uses, see Dalles. Not to be confused with the town of Dallas, Oregon. City in Wasco County The Dalles City The Dalles and the Columbia River in November 2008 Flag Seal Motto(s): "Cognito timor Vincit" (Latin), "Knowledge Conquers Fear" (English) Location in Oregon Coordinates: 45°36′4″N 121°10′58″W / 45.60111°N 121.18278°W / 45.60111; -121.18278 Coordinates: 45°36′4″N 121°10′58″W / 45.60111°N 121.18278°W / 45.60111; -121.18278 County Wasco County Incorporated 1857 Government • Mayor Stephen Elliott Lawrence (D) [1] [2] Area [3] • Total 6.61 sq mi (17.12...
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