Lenograstim
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Lenograstim
| Clinical data |
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| Trade names |
Euprotin, Granocyte, Lenobio, Neutrogin |
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AHFS/Drugs.com
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International Drug Names
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| ATC code |
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| Identifiers |
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| CAS Number |
135968-09-1 N
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| ChemSpider |
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| UNII |
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| ECHA InfoCard |
100.207.855  |
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N Y (what is this?) (verify)
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Lenograstim is a recombinant granulocyte colony-stimulating factor which functions as an immunostimulator.[1][2] It is developed by Chugai Pharmaceuticals under the brand name Granocyte.
References[edit]
^ "USAN Council. List No. 340. New names. Lenograstim". Clin. Pharmacol. Ther. 52 (1): 113. July 1992. doi:10.1038/clpt.1992.117. PMID 1284891..mw-parser-output cite.citationfont-style:inherit.mw-parser-output qquotes:"""""""'""'".mw-parser-output code.cs1-codecolor:inherit;background:inherit;border:inherit;padding:inherit.mw-parser-output .cs1-lock-free abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-lock-subscription abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registrationcolor:#555.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration spanborder-bottom:1px dotted;cursor:help.mw-parser-output .cs1-hidden-errordisplay:none;font-size:100%.mw-parser-output .cs1-visible-errorfont-size:100%.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-formatfont-size:95%.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-leftpadding-left:0.2em.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-rightpadding-right:0.2em
^ Amadori S, Suciu S, Jehn U, Stasi R, Thomas X, Marie JP, Muus P, Lefrère F, Berneman Z, Fillet G, Denzlinger C, Willemze R, Leoni P, Leone G, Casini M, Ricciuti F, Vignetti M, Beeldens F, Mandelli F, De Witte T (July 2005). "Use of glycosylated recombinant human G-CSF (lenograstim) during and/or after induction chemotherapy in patients 61 years of age and older with acute myeloid leukemia: final results of AML-13, a randomized phase-3 study". Blood. 106 (1): 27–34. doi:10.1182/blood-2004-09-3728. PMC 1895135. PMID 15761020.
Immunostimulants (L03)
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| Endogenous |
| Cytokines |
| Colony-stimulating factors |
G-CSF
Filgrastim / Pegfilgrastim
- Lenograstim
GM-CSF
SCF
|
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| Interferons |
alpha:
- Albinterferon
Interferon alfa natural
Interferon alfa 2a / Peginterferon alfa-2a
Interferon alfa 2b / Peginterferon alfa-2b
- Interferon alfa n1
- Interferon alfacon-1
- Interferon alpha-n3
beta:
Interferon beta natural
- Interferon beta 1a
- Interferon beta 1b
- Interferon gamma
|
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| Interleukins |
|
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|
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| Other protein / peptide |
- Growth hormone
- Immunocyanin
- Pegademase
- Prolactin
- Tasonermin
|
|---|
| Other |
- Female sex steroids
- Histamine dihydrochloride
- Poly ICLC
- Vitamin D
|
|---|
|
|---|
| Exogenous |
beta-glucan
heterocyclic compound
hydroxyquinoline
- Mifamurtide
oligopeptides
- Glatiramer acetate
- Thymopentin
- Thymosin α1
- Thymulin
polyribonucleotide
- Polyinosinic:polycytidylic acid
thiazolidine
vaccines
- Bacillus Calmette–Guérin
- Melanoma vaccine
- Sipuleucel-T
|
|---|
Cytokine receptor modulators
|
|---|
| Chemokine |
|
|---|
| CSF |
| Erythropoietin |
Agonists: ARA-290
- Asialo erythropoietin
- Carbamylated erythropoietin
- CNTO-530
- Darbepoetin alfa
- Epoetin alfa
- Epoetin beta
- Epoetin delta
- Epoetin epsilon
- Epoetin gamma
- Epoetin kappa
- Epoetin omega
- Epoetin theta
- Epoetin zeta
- Erythropoietin (EPO)
- Erythropoietin-Fc
- Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
- Peginesatide
- Pegol sihematide (EPO-018B)
|
|---|
| G-CSF (CSF3) |
Agonists: Filgrastim
- Granulocyte colony-stimulating factor
- Lenograstim
- Leridistim
- Lipegfilgrastim
- Nartograstim
- Pegfilgrastim
- Pegnartograstim
|
|---|
| GM-CSF (CSF2) |
Agonists: Ecogramostim
- Granulocyte macrophage colony-stimulating factor
- Milodistim
- Molgramostim
- Regramostim
- Sargramostim
Antibodies: Mavrilimumab
- MOR103
- Namilumab
|
|---|
| M-CSF (CSF1) |
Agonists: Cilmostim
- Interleukin-34
- Lanimostim
- Macrophage colony-stimulating factor
- Mirimostim
Kinase inhibitors: Agerafenib
|
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| SCF (c-Kit) |
|
|---|
| Thrombopoietin |
Agonists: Eltrombopag
- Pegacaristim
- Promegapoietin
- Romiplostim
- Thrombopoietin (THPO, MGDF)
|
|---|
|
|---|
| Interferon |
| IFNAR (α/β, I) |
Agonists: Albinterferon
- Interferon alpha (interferon alfa, IFN-α)
Interferon alfa (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21)
- Interferon alfa 2a
- Interferon alfa 2b
- Interferon alfa n1
- Interferon alfacon-1
- Interferon alpha-n3
Interferon beta (IFN-β) (IFNB1, IFNB3)
- Interferon beta 1a
- Interferon beta 1b
- Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
- Interferon omega (IFN-ω, IFNW1)
- Peginterferon alfa-2a
- Peginterferon alfa-2b
Antibodies: Anifrolumab
- Faralimomab
- MEDI-545
- Rontalizumab
- Sifalimumab
Decoy receptors: Bifarcept
|
|---|
| IFNGR (γ, II) |
Agonists: Interferon gamma (IFN-γ)
- Interferon gamma 1b
Antibodies: Emapalumab
- Fontolizumab
|
|---|
| IFNLR (λ, III) |
- See IL-28R (IFNLR) here instead.
|
|---|
|
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| Interleukin |
|
|---|
| TGFβ |
|
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| TNF |
|
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| Others |
JAK (inhibitors)
|
| JAK1 |
- Baricitinib
- Filgotinib
- Momelotinib
- Oclacitinib
- Ruxolitinib
- Tofacitinib (tasocitinib, CP-690550)
- Upadacitinib
|
|---|
| JAK2 |
- AG-490
- Atiprimod
- AZD-1480
- Baricitinib
- CHZ868
- Cucurbitacin I (elatericin B, JSI-124)
- CYT387
- Lestaurtinib
- NSC-7908
- NSC-33994
- Pacritinib
- Ruxolitinib
- SD-1008
- Tofacitinib (tasocitinib, CP-690550)
|
|---|
| JAK3 |
- AG-490
- Cercosporamide
- TCS-21311
- Tofacitinib (tasocitinib, CP-690550)
- WHI-P 154
- ZM-39923
- ZM-449829
|
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|
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| Others |
Additional cytokines: Cardiotrophin 1 (CT-1)
- FMS-like tyrosine kinase 3 ligand (FLT3L)
- Leukemia/leukocyte inhibitory factor (LIF)
- Oncostatin M (OSM)
- Thymic stromal lymphopoietin (TSLP)
Additional cytokine receptor modulators: Emfilermin
- Lestaurtinib
- Midostaurin
- Quizartinib
- Sorafenib
- Sunitinib
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- See also
- Receptor/signaling modulators
- Signaling peptide/protein receptor modulators
- Growth factor receptor modulators
|
Growth factor receptor modulators
|
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| Angiopoietin |
Agonists: Angiopoietin 1
- Angiopoietin 4
Antagonists: Angiopoietin 2
- Angiopoietin 3
Kinase inhibitors: Altiratinib
- CE-245677
- Rebastinib
Antibodies: Evinacumab (against angiopoietin 3)
Nesvacumab (against angiopoietin 2)
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| CNTF |
Agonists: Axokine
- CNTF
- Dapiclermin
|
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| EGF (ErbB) |
EGF (ErbB1/HER1)
|
Agonists: Amphiregulin
- Betacellulin
- EGF (urogastrone)
- Epigen
- Epiregulin
- Heparin-binding EGF-like growth factor (HB-EGF)
- Murodermin
- Nepidermin
- Transforming growth factor alpha (TGFα)
Kinase inhibitors: Afatinib
- AG-490
- Agerafenib
- Brigatinib
- Canertinib
- Dacomitinib
- Erlotinib
- Gefitinib
- Grandinin
- Icotinib
- Lapatinib
- Neratinib
- Osimertinib
- Vandetanib
- WHI-P 154
Antibodies: Cetuximab
- Depatuxizumab
- Depatuxizumab mafodotin
- Futuximab
- Imgatuzumab
- Matuzumab
- Necitumumab
- Nimotuzumab
- Panitumumab
- Zalutumumab
|
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| ErbB2/HER2 |
Antibodies: Ertumaxomab
- Pertuzumab
- Trastuzumab
- Trastuzumab duocarmazine
- Trastuzumab emtansine
Kinase inhibitors: Afatinib
- AG-490
- Lapatinib
- Mubritinib
- Neratinib
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| ErbB3/HER3 |
Agonists: Neuregulins (heregulins) (1, 2, 6 (neuroglycan C))
Antibodies: Duligotumab
- Patritumab
- Seribantumab
|
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| ErbB4/HER4 |
Agonists: Betacellulin
- Epigen
- Heparin-binding EGF-like growth factor (HB-EGF)
Neuregulins (heregulins) (1, 2, 3, 4, 5 (tomoregulin, TMEFF))
|
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|
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| FGF |
| FGFR1 |
Agonists: Ersofermin
FGF (1, 2 (bFGF), 3, 4, 5, 6, 8, 10 (KGF2), 20)
- Repifermin
- Trafermin
- Velafermin
|
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| FGFR2 |
Agonists: Ersofermin
FGF (1, 2 (bFGF), 3, 4, 5, 6, 7 (KGF), 8, 9, 10 (KGF2), 17, 18, 22)
- Palifermin
- Repifermin
- Sprifermin
- Trafermin
Antibodies: Aprutumab
- Aprutumab ixadotin
|
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| FGFR3 |
Agonists: Ersofermin
FGF (1, 2 (bFGF), 4, 8, 9, 18, 23)
- Sprifermin
- Trafermin
Antibodies: Burosumab (against FGF23)
|
|---|
| FGFR4 |
Agonists: Ersofermin
FGF (1, 2 (bFGF), 4, 6, 8, 9, 19)
- Trafermin
|
|---|
| Unsorted |
|
|---|
|
|---|
| HGF (c-Met) |
Agonists: Hepatocyte growth factor
Potentiators: Dihexa (PNB-0408)
Kinase inhibitors: Altiratinib
- AM7
- AMG-458
- Amuvatinib
- BMS-777607
- Cabozantinib
- Crizotinib
- Foretinib
- Golvatinib
- INCB28060
- JNJ-38877605
- K252a
- MK-2461
- PF-04217903
- PF-2341066
- PHA-665752
- SU-11274
- Tivantinib
- Volitinib
Antibodies: Emibetuzumab
- Ficlatuzumab
- Flanvotumab
- Onartuzumab
- Rilotumumab
- Telisotuzumab
- Telisotuzumab vedotin
|
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| IGF |
| IGF-1 |
Agonists: des(1-3)IGF-1
- Insulin-like growth factor-1 (somatomedin C)
- IGF-1 LR3
- Insulin-like growth factor-2 (somatomedin A)
- Insulin
- Mecasermin
- Mecasermin rinfabate
Kinase inhibitors: BMS-754807
- Linsitinib
- NVP-ADW742
- NVP-AEW541
- OSl-906
Antibodies: AVE-1642
- Cixutumumab
- Dalotuzumab
- Figitumumab
- Ganitumab
- Robatumumab
- R1507
- Teprotumumab
Xentuzumab (against IGF-1 and IGF-2)
|
|---|
| IGF-2 |
Agonists: Insulin-like growth factor-2 (somatomedin A)
Antibodies: Dusigitumab
Xentuzumab (against IGF-1 and IGF-2)
|
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| Others |
Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7)
Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1)
- Trofinetide
|
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|
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| LNGF (p75NTR) |
Agonists: BDNF
- BNN-20
- BNN-27
- Cenegermin
- DHEA
- DHEA-S
- NGF
- NT-3
- NT-4
Antagonists: ALE-0540
- Dexamethasone
- EVT-901 (SAR-127963)
- Testosterone
Antibodies: Against NGF: ABT-110 (PG110)
- ASP-6294
- Fasinumab
- Frunevetmab
- Fulranumab
- MEDI-578
- Ranevetmab
- Tanezumab
Aptamers: Against NGF: RBM-004
Decoy receptors: LEVI-04 (p75NTR-Fc)
|
|---|
| PDGF |
Agonists: Becaplermin
Platelet-derived growth factor (A, B, C, D)
Kinase inhibitors: Agerafenib
- Axitinib
- Crenolanib
- Imatinib
- Lenvatinib
- Masitinib
- Motesanib
- Nintedanib
- Pazopanib
- Radotinib
- Quizartinib
- Sunitinib
- Sorafenib
- Toceranib
Antibodies: Olaratumab
- Ramucirumab
- Tovetumab
|
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| RET (GFL) |
| GFRα1 |
Agonists: Glial cell line-derived neurotrophic factor (GDNF)
- Liatermin
Kinase inhibitors: Vandetanib
|
|---|
| GFRα2 |
Agonists: Neurturin (NRTN)
Kinase inhibitors: Vandetanib
|
|---|
| GFRα3 |
Kinase inhibitors: Vandetanib
|
|---|
| GFRα4 |
Agonists: Persephin (PSPN)
Kinase inhibitors: Vandetanib
|
|---|
| Unsorted |
Kinase inhibitors: Agerafenib
|
|---|
|
|---|
| SCF (c-Kit) |
Agonists: Ancestim
- Stem cell factor
Kinase inhibitors: Agerafenib
- Axitinib
- Dasatinib
- Imatinib
- Masitinib
- Nilotinib
- Pazopanib
- Quizartinib
- Sorafenib
- Sunitinib
- Toceranib
|
|---|
| TGFβ |
|
|---|
| Trk |
| TrkA |
Agonists: Amitriptyline
- BNN-20
- BNN-27
- Cenegermin
- DHEA
- DHEA-S
- Gambogic amide
- NGF
- Tavilermide
Antagonists: ALE-0540
- Dexamethasone
- FX007
- Testosterone
Negative allosteric modulators: VM-902A
Kinase inhibitors: Altiratinib
- AZD-6918
- CE-245677
- CH-7057288
- DS-6051
- Entrectinib
- GZ-389988
- K252a
- Larotrectinib
- Lestaurtinib
- Milciclib
- ONO-4474
- ONO-5390556
- PLX-7486
- Rebastinib
SNA-120 (pegylated K252a))
Antibodies: Against TrkA: GBR-900; Against NGF: ABT-110 (PG110)
- ASP-6294
- Fasinumab
- Frunevetmab
- Fulranumab
- MEDI-578
- Ranevetmab
- Tanezumab
Aptamers: Against NGF: RBM-004
Decoy receptors: ReN-1820 (TrkAd5)
|
|---|
| TrkB |
Agonists: 3,7-DHF
- 3,7,8,2'-THF
- 4'-DMA-7,8-DHF
- 7,3'-DHF
- 7,8-DHF
- 7,8,2'-THF
- 7,8,3'-THF
- Amitriptyline
- BDNF
- BNN-20
- Deoxygedunin
- Deprenyl
- Diosmetin
- DMAQ-B1
- HIOC
- LM22A-4
- N-Acetylserotonin
- NT-3
- NT-4
- Norwogonin (5,7,8-THF)
- R7
- R13
- TDP6
Antagonists: ANA-12
- Cyclotraxin B
- Gossypetin (3,5,7,8,3',4'-HHF)
Kinase inhibitors: Altiratinib
- AZD-6918
- CE-245677
- CH-7057288
- DS-6051
- Entrectinib
- GZ-389988
- K252a
- Larotrectinib
- Lestaurtinib
- ONO-4474
- ONO-5390556
- PLX-7486
|
|---|
| TrkC |
Kinase inhibitors: Altiratinib
- AZD-6918
- CE-245677
- CH-7057288
- DS-6051
- Entrectinib
- GZ-389988
- K252a
- Larotrectinib
- Lestaurtinib
- ONO-4474
- ONO-5390556
- PLX-7486
|
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|
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| VEGF |
Agonists: Placental growth factor (PGF)
- Telbermin
VEGF (A, B, C, D (FIGF))
Allosteric modulators: Cyclotraxin B
Kinase inhibitors: Agerafenib
- Altiratinib
- Axitinib
- Cabozantinib
- Cediranib
- Lapatinib
- Lenvatinib
- Motesanib
- Nintedanib
- Pazopanib
- Pegaptanib
- Rebastinib
- Regorafenib
- Semaxanib
- Sorafenib
- Sunitinib
- Toceranib
- Tivozanib
- Vandetanib
- WHI-P 154
Antibodies: Alacizumab pegol
- Bevacizumab
- Icrucumab
- Ramucirumab
- Ranibizumab
Decoy receptors: Aflibercept
|
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| Others |
Additional growth factors: Adrenomedullin
Colony-stimulating factors (see here instead)
- Connective tissue growth factor (CTGF)
Ephrins (A1, A2, A3, A4, A5, B1, B2, B3)
Erythropoietin (see here instead)
- Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
- Glia maturation factor (GMF)
- Hepatoma-derived growth factor (HDGF)
Interleukins/T-cell growth factors (see here instead)
- Leukemia inhibitory factor (LIF)
- Macrophage-stimulating protein (MSP; HLP, HGFLP)
- Midkine (NEGF2)
- Migration-stimulating factor (MSF; PRG4)
- Oncomodulin
- Pituitary adenylate cyclase-activating peptide (PACAP)
- Pleiotrophin
- Renalase
Thrombopoietin (see here instead)
- Wnt signaling proteins
Additional growth factor receptor modulators: Cerebrolysin (neurotrophin mixture)
|
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- See also
- Receptor/signaling modulators
- Signaling peptide/protein receptor modulators
- Cytokine receptor modulators
|

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